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TranscriptomicsDeregulation of the endogenous C/EBPM-NM-2 LIP isoform predisposes to tumorigenesis
Two long and one truncated isoforms (termed LAP*, LAP, and LIP, respectively) of the transcription factor CCAAT enhancer binding protein beta (C/EBPM-NM-2) are expressed from a single intronless Cebpb gene by alternative translation initiation. Isoform expression is sensitive to mammalian target of ...
ORGANISM(S): Mus musculus 
2014-12-16 | E-GEOD-53770 | biostudies-arrayexpress
TranscriptomicsSmallpox vaccination with LC16m8 vaccinia virus provides a gene expression profile similar to DryVax vaccination
Transcriptional analysis of global gene expression changes in naïve subjects in response to smallpox vaccination with either DryVax or the replication-competent, attenuated LC16m8 vaccinia virus. Subjects were vaccinated with either DryVax or LC16m8 (5 from each group), and blood samples were taken ...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-22121 | biostudies-arrayexpress
TranscriptomicsLoss-of-function of MYO5B induces epithelial cell scattering in enterocytes
A non-functional myosin Vb motor in duodenal enterocytes results in disruption of epithelial cell polarity characterized by complete loss of microvilli and mislocalization of apical brush border proteins in the cytoplasm which finally cause a devastating disease in neonates with severe malabsorption...
ORGANISM(S): Homo sapiens 
2013-03-14 | E-GEOD-45134 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of ex vivo isolated inflammed mouse lymphatic endothelial cells
Chemokines and adhesion molecules upregulated in lymphatic endothelial cells (LECs) during tissue inflammation are believed to enhance dendritic cell (DC) migration to draining lymph nodes (dLNs), but the in vivo control of this process is not well understood. By performing transcriptional profiling...
ORGANISM(S): Mus musculus 
2011-05-19 | E-GEOD-26229 | biostudies-arrayexpress
TranscriptomicsSaccharomyces cerevisiae sorted and untreated
Gene expression of a vital, stained and sorted subpopulation of Saccharomyces cerevisiae with high affinity to glucose, harvested at a dilution rate of D=0.160 h-1, and of cells from the whole population without further treatment grown at the same dilution rate were analysed. The isolation of RNA wa...
ORGANISM(S): Saccharomyces cerevisiae 
2007-10-01 | E-GEOD-8247 | biostudies-arrayexpress
TranscriptomicsInfluenza peptide reactivity within a cohort of age-stratified individuals pre and post vaccination with the 2008/2009 trivalent influenza vaccine
The aim of the study was to test the hypothesis that peptide array reactivity will reveal patterns that can be associated with poor or effective neutralization response to seasonal influenza vaccine We diluted patient sera 1:80 and incubated dilutions on a streptavidin-coated glass surface that was ...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-43446 | biostudies-arrayexpress
TranscriptomicsGenomic Response of Escherichia coli during coexpression of a bacteriocin release protein
Secretion of recombinant proteins to the culture medium after transport to the periplasm of gram-negative bacteria often facilitates downstream-processing. It could lead to more biological active and correct folded proteins and low contamination with host proteins, thereby reducing the costs of the ...
ORGANISM(S): Escherichia coli 
2009-08-01 | E-GEOD-16946 | biostudies-arrayexpress
GenomicsGenetic measurement of memory B-cell recall using antibody repertoire sequencing

We developed an improved high throughput sequencing approach to measure the quantities and sequences of the repertoire of antibody heavy chain RNA in a blood sample. Using this approach we analyzed the antibody repertoire in response to yearly vaccinations with influenza vaccines TIV and LAIV in ...

phs000656.v1.p1 | EGA
TranscriptomicsTranscription profiling of liver and small intestine from Cyp3a/Mdr1a/1b knock-out mice and wild-type mice
comparison Cyp3a/Mdr1a/1b ko mice with wild-type mice (both FVB background)
ORGANISM(S): Mus musculus 
2009-07-01 | E-NCMF-26 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human EBV transformed cell lines established from patients with a novel immunodeficiency syndrome
Lysosome-related organelles have versatile functions including protein and lipid degradation, signal transduction, and protein secretion. The molecular elucidation of rare congenital diseases affecting endosomal/lysosomal biogenesis has given insights into physiological functions of the innate and a...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6322 | biostudies-arrayexpress
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