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MetabolomicsCeramide Promotes Lytic Reactivation of Epstein-Barr Virus in Gastric Carcinoma
Epstein-Barr virus (EBV) has a lifelong latency period after initial infection. Rarely, however, when the EBV immediate early gene BZLF1 is expressed by a specific stimulus, the virus switches to the lytic cycle to produce progeny viruses. We found that EBV infection reduced levels of various cerami...
2023-12-20 | MTBLS7649 | MetaboLights
TranscriptomicsEpstein-Barr virus growth/latency III program alters cellular microRNA expression
The Epstein-Barr virus (EBV) is associated with lymphoid and epithelial cancers. Initial EBV infection alters lymphocyte gene expression, inducing cellular proliferation and differentiation as the virus transitions through consecutive latency transcription programs. Cellular microRNAs (miRNAs) are...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-13056 | biostudies-arrayexpress
TranscriptomicsGene expression changes in subclones of a Burkitt lymphoma cell line with different patterns of EBV latent infection
In this study we have investigated the gene expression profiles of three different types of subclone all generated by single cell cloning of the same parental EBV positive Burkitt lymphoma cell line Awia-BL. These included EBV negative clones which have lost the virus episome, EBV positive clones w...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-42867 | biostudies-arrayexpress
ModelsAguilera 2014 - HIV latency. Interaction between HIV proteins and immune response
Aguilera 2014 - HIV latency. Interaction between HIV proteins and immune response This model is described in the article: Studying HIV latency by modeling the interaction between HIV proteins and the innate immune response. Aguilera LU, Rodríguez-González J. J. Theor. Biol...
2024-09-02 | BIOMD0000000573 | BioModels
TranscriptomicsEpstein-Barr virus maintains lymphomas via its miRNAs
EpsteinM-bM-^@M-^PBarr virus (EBV) has evolved exquisite controls over its host cells, human B lymphocytes, not only directing these cells during latency to proliferate and thereby expand the pool of infected cells, but also to survive and thereby persist for the lifetime of the infected individual....
ORGANISM(S): Homo sapiens 
2013-04-30 | E-GEOD-44769 | biostudies-arrayexpress
TranscriptomicsThe role of antigen presenting cells in the induction of HIV-1 latency in resting CD4+ T-cells
BACKGROUND: Combination antiretroviral therapy (cART) is able to control HIV-1 viral replication, however long-lived latent infection in resting memory CD4+ T-cells persist. The mechanisms for establishment and maintenance of latent infection in resting memory CD4+ T-cells remain unclear. Previously...
ORGANISM(S): Homo sapiens 
2015-12-23 | E-GEOD-70106 | biostudies-arrayexpress
TranscriptomicsHost Cell Gene Expression During HIV-1 Latency and Reactivation
Cells: ACH-2, and A3.01, were obtained through the NIH AIDS Research and Reference Reagent Program, Division of AIDS, NIAID, NIH. ACH-2, is a chronically infected cell line harboring HIV-1 LAV strain, while A3.01 is the corresponding parental uninfected cell line. Cells were grown in RPMI-1640 (Inv...
ORGANISM(S): Homo sapiens 
2010-06-06 | E-GEOD-1441 | biostudies-arrayexpress
TranscriptomicsHelminth Infection Reactivates Latent γ-herpesvirus Via Cytokine Competition at a Viral Promoter
Mammals are co-infected by multiple pathogens that interact through unknown mechanisms. We found that helminth infection, characterized by the induction of the cytokine interleukin-4 (IL-4) and the activation of the transcription factor Stat6, reactivated murine gammaherpesvirus infection in vivo. I...
ORGANISM(S): Mus musculus 
2014-06-26 | E-GEOD-58116 | biostudies-arrayexpress
TranscriptomicsmicroRNA-155 is an Epstein-Barr Virus induced gene that modulates EBV-regulated gene expression (microRNA-155 infection)
The cellular microRNA, miR-155 has been shown to be involved in lymphocyte activation and is expressed in EBV infected cells displaying type III latency gene expression but not type I latency gene expression. We show here that the elevated levels of miR-155 in type III latency cells is due to EBV g...
ORGANISM(S): Homo sapiens 
2008-03-17 | E-GEOD-10864 | biostudies-arrayexpress
TranscriptomicsHost Cell Gene Expression During HIV-1 Latency in Chronically Infected Cell Lines
Cells: ACH-2, A3.01, J1.1, and U1 cells were obtained through the NIH AIDS Research and Reference Reagent Program, Division of AIDS, NIAID, NIH. U-937 cells were obtained from American Type Culture Collection (Manassas, VA). ACH-2, J1.1 and U1 are chronically infected cell lines harboring HIV-1 LA...
ORGANISM(S): Homo sapiens 
2010-06-06 | E-GEOD-1443 | biostudies-arrayexpress
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