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Aguilera 2014 - HIV latency. Interaction between HIV proteins and immune response


ABSTRACT: Aguilera 2014 - HIV latency. Interaction between HIV proteins and immune response This model is described in the article: Studying HIV latency by modeling the interaction between HIV proteins and the innate immune response. Aguilera LU, Rodríguez-González J. J. Theor. Biol. 2014 Nov; 360: 67-77 Abstract: HIV infection leads to two cell fates, the viral productive state or viral latency (a reversible non-productive state). HIV latency is relevant because infected active CD4+ T-lymphocytes can reach a resting memory state in which the provirus remains silent for long periods of time. Despite experimental and theoretical efforts, the causal molecular mechanisms responsible for HIV latency are only partially understood. Studies have determined that HIV latency is influenced by the innate immune response carried out by cell restriction factors that inhibit the postintegration steps in the virus replication cycle. In this study, we present a mathematical study that combines deterministic and stochastic approaches to analyze the interactions between HIV proteins and the innate immune response. Using wide ranges of parameter values, we observed the following: (1) a phenomenological description of the viral productive and latent cell phenotypes is obtained by bistable and bimodal dynamics, (2) biochemical noise reduces the probability that an infected cell adopts the latent state, (3) the effects of the innate immune response enhance the HIV latency state, (4) the conditions of the cell before infection affect the latent phenotype, i.e., the existing expression of cell restriction factors propitiates HIV latency, and existing expression of HIV proteins reduces HIV latency. This model is hosted on BioModels Database and identified by: BIOMD0000000573. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

DISEASE(S): Human Immunodeficiency Virus Infectious Disease

SUBMITTER: Luis Ubaldo Aguilera de Lira  

PROVIDER: BIOMD0000000573 | BioModels | 2015-03-30

REPOSITORIES: BioModels

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Studying HIV latency by modeling the interaction between HIV proteins and the innate immune response.

Aguilera Luis U LU   Rodríguez-González Jesús J  

Journal of theoretical biology 20140702


HIV infection leads to two cell fates, the viral productive state or viral latency (a reversible non-productive state). HIV latency is relevant because infected active CD4+ T-lymphocytes can reach a resting memory state in which the provirus remains silent for long periods of time. Despite experimental and theoretical efforts, the causal molecular mechanisms responsible for HIV latency are only partially understood. Studies have determined that HIV latency is influenced by the innate immune resp  ...[more]

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