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TranscriptomicsUnderstanding Vitamin D resistance using Nonsense Mediated Decay arrays
Vitamin D is the strongest known natural anti-proliferative. A large number of studies in a wide spectrum of cancers, including epidemiological, in vitro and animal models, demonstrate that the active form of Vitamin D has anti-cancer benefits, affecting both progression and metastasis. Alike the ro...
ORGANISM(S): Homo sapiens 
2008-06-01 | E-GEOD-9959 | biostudies-arrayexpress
TranscriptomicsUnderstanding Vitamin D resistance using expression microarrays
Vitamin D is the strongest known natural anti-proliferative. A large number of studies in a wide spectrum of cancers, including epidemiological, in vitro and animal models, demonstrate that the active form of Vitamin D has anti-cancer benefits, affecting both progression and metastasis. Alike the ro...
ORGANISM(S): Homo sapiens 
2008-05-31 | E-GEOD-9867 | biostudies-arrayexpress
TranscriptomicsUnderstanding Vitamin D resistance using array comparative genomic hybridization
Vitamin D is the strongest known natural anti-proliferative. A large number of studies in a wide spectrum of cancers, including epidemiological, in vitro and animal models, demonstrate that the active form of Vitamin D has anti-cancer benefits, affecting both progression and metastasis. Alike the ro...
ORGANISM(S): Homo sapiens 
2008-05-31 | E-GEOD-9887 | biostudies-arrayexpress
TranscriptomicsHuman Corneal Epithelial Cells (SV40-HCEC) 6h Treatment with 100nM Vitamin D (1,25D3) vs. Vehicle Control
Inflammatory signals must be regulated and kept in check in order to prevent tissue damage.  This is especially true in the cornea, where damage can induce loss of transparency, essential for vision.  Toll-like receptors (TLRs) are present at the ocular surface and, in addition to being protective...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-72663 | biostudies-arrayexpress
TranscriptomicsTranscriptomics of vitamin D treatment effects in Mycobacterium tuberculosis-infected THP-1 cells
Previous reports have shown low vitamin D serum levels and polymorphisms in the vitamin D receptor (VDR) to be associated with increased risk for TB. Given that 1?,25-dihydroxyvitamin D3 has a role in lipid metabolism control, we tested whether the link between 1?,25-dihydroxyvitamin D3 and tubercul...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-57028 | biostudies-arrayexpress
TranscriptomicsHuman Corneal Epithelial Cells (hTCEpi) 6h Treatment with 100nM Vitamin D (1,25D3) vs. Vehicle Control
Inflammatory signals must be regulated and kept in check in order to prevent tissue damage. This is especially true in the cornea, where damage can induce loss of transparency, essential for vision. Toll-like receptors (TLRs) are present at the ocular surface and, in addition to being protective a...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-72662 | biostudies-arrayexpress
TranscriptomicsVitamin D treatment of M.tb. infected macrophages
As macrophages are the primary site of Mtb infection and are sites of vitamin D signaling, we have used these cells to understand the molecular mechanisms underlying modulation of the immune response by the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25D). Microarrays were used to measure...
ORGANISM(S): Homo sapiens 
2013-11-28 | E-GEOD-52819 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human activated T lymphocytes to determine the effects of TX527, a hypocalcemic vitamin D analog
Hypocalcemic vitamin D analogs are appealing molecules to exploit the immunomodulatory actions of active vitamin D in vivo. The functional modulation of dendritic cells is regarded as the key mechanism underlying their ability to regulate T cell responses. In contrast, the direct actions of vitamin ...
ORGANISM(S): Homo sapiens 
2010-11-15 | E-GEOD-23984 | biostudies-arrayexpress
TranscriptomicsAnalysis of vitamin D response element binding protein target genes reveals a role for vitamin D in osteoblast mTOR signaling
Heterogeneous nuclear ribonucleoprotein (hnRNP) C1/C2 plays a pivotal role in vitamin D receptor (VDR) signaling by acting as a vitamin D response element (VDRE)-binding protein (VDRE-BP). Transcriptional regulation by active 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) involves occupancy of VDRE by VDRE-...
ORGANISM(S): Homo sapiens 
2010-11-19 | E-GEOD-22523 | biostudies-arrayexpress
TranscriptomicsVitamin D modulation of innate immune signalling in Dendritic Cells
Vitamin D is widely reported to inhibit innate immune signalling and dendritic cell (DC) maturation, leading to attenuation of DC mediated T cell activation as a potential immunoregulatory mechanism to guard against autoimmunity and immmunopathology. It is not known whether vitamin D has global or g...
ORGANISM(S): Homo sapiens 
2016-10-03 | E-MTAB-4883 | biostudies-arrayexpress
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