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TranscriptomicsEffect of simvastatin on pancreatic cancer cells
The aim of our study was to assess the impact of simvastatin on the amount of cytosolic lipid droplets (LDs), which are implicated in many biological processes including proliferation, inflammation, carcinogenesis, apoptosis, necrosis or growth arrest. Human pancreatic cancer cells MiaPaCa-2 were t...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-MTAB-1501 | biostudies-arrayexpress
TranscriptomicsRole of mevalonate pathway intermediates in anticancer effect of statins
Simvastatin has been widely used for treatment of hypercholesterolemia due to its ability to inhibit HMG-CoA reductase, the rate limiting enzyme of de novo cholesterol synthesis via mevalonate pathway. Its inhibitory action causes also depletion of pathway intermediates, farnesyl pyrophosphate (FPP)...
ORGANISM(S): Homo sapiens 
2018-03-31 | E-MTAB-3263 | biostudies-arrayexpress
TranscriptomicsStatins-induced changes in gene expression of pancreatic cancer cells with focus on anti-proliferative effects of statins.
Statins, potent lipid-lowering drugs, were also shown to exert anti-proliferative activity. The aim of this study was to identify the biological pathways affected by changes in gene expression activity after statins treatment and to compare the results with observed anti-proliferative effects. The s...
ORGANISM(S): Homo sapiens 
2017-12-30 | E-MTAB-3979 | biostudies-arrayexpress
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