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TranscriptomicsFezf2 overexpression in murine cortical progenitors in vivo
Corticospinal motor neurons (CSMN) are one specialized class of cortical excitatory neurons, which connect layer Vb of the cortex to the spinal cord. a master transcription factor –Forebrain expressed zinc finger 2 (Fezf2) – has been identified that is necessary for the fate specification of CSMN. F...
ORGANISM(S): Mus musculus 
2014-07-06 | E-GEOD-56451 | biostudies-arrayexpress
TranscriptomicsA SUMOylated C-terminus fragment of glutamate transporter EAAT2 linked to inherited ALS mediates motor axon impairment
Downregulation of expression and activity levels of the astroglial glutamate transporter EAAT2 is thought to be implicated in motor neuron excitotoxicity in amyotrophic lateral sclerosis (ALS). We previously reported that EAAT2 is cleaved by caspase-3 at the cytosolic C-terminus domain, impairing th...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-26070 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse FACS purified cortical projection neurons
3 subtypes of cortical projection neurons were purified by fluorescence-activated cell sorting at 4 different stages of development from mouse cortex. A detailed description of the data set is described in Arlotta, P et al (2005)
ORGANISM(S): Mus musculus 
2007-11-20 | E-GEOD-2039 | biostudies-arrayexpress
TranscriptomicsGlobal changes in gene expression in dermal fibroblasts with in vivo and in vitro deletion of the RBP-Jk gene
It is currently unclear whether tissue changes surrounding multifocal epithelial tumors are a cause or consequence of cancer. Here, we provide evidence that loss of mesenchymal Notch/CSL signaling causes tissue alterations, including stromal atrophy and inflammation, which precede and are potent tri...
ORGANISM(S): Mus musculus 
2012-06-11 | E-GEOD-36359 | biostudies-arrayexpress
TranscriptomicsExpression data of hepatic iNKT cells from pLck-hCD1d transgenic mice
CD1d expression by thymocytes is required to select iNKT cells. When CD1d is expressed only on thymocytes (pLck-CD1d tg mice), iNKT cells are hyperresponsive to antigen stimulation suggesting that, in physiological conditions, these cells undergo functional education mediated by additional CD1d-expr...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-42835 | biostudies-arrayexpress
MetabolomicsPomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs
Plant extracts are rich in bioactive compounds, such as polyphenols, sesquiterpenes, and triterpenes, which potentially have antiviral activities. As a consequence of the coronavirus disease 2019 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, thousands of...
2021-10-06 | MTBLS2309 | MetaboLights
TranscriptomicsIn vitro and in vivo evidences of osteocytes involvement in myeloma-induced osteoclast formation and bone disease
The involvement of osteocytes in multiple myeloma (MM)-induced osteoclast formation and the occurrence of bone lesions are still unknown. Osteocytes regulate bone remodeling at least in part through the cell death and apoptosis triggering osteoclast recruitment and formation. In this study, firstly ...
ORGANISM(S): Homo sapiens 
2012-05-21 | E-GEOD-27372 | biostudies-arrayexpress
MetabolomicsMetabolomics profiling of pre-and post-anesthesia plasma samples obtained via Ficoll separation
1H Nuclear Magnetic Resonance (NMR) spectroscopy was used to investigate the metabolic consequences of general anesthesia in the plasma of two groups of patients with diagnosis for non-metastatic colorectal cancer and metastatic colorectal cancer with liver-metastasis, respectively. Patients were tr...
2015-11-17 | MTBLS172 | MetaboLights
UnknownDistinct Cytokine Landscapes Induced by Influenza a Virus, RSV, and SARS-CoV-2 in Older Adults (65+) Using an Ex Vivo Whole Blood Stimulation Model
Not available
S-EPMC12943484 | biostudies-literature
MetabolomicsMetabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab
The current pandemic emergence of novel coronavirus disease (COVID-19) poses a relevant threat to global health. SARS-CoV-2 infection is characterized by a wide range of clinical manifestations, ranging from absence of symptoms to severe forms that need intensive care treatment. Here, plasma-EDTA sa...
2022-02-21 | MTBLS2336 | MetaboLights
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