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ProteomicsContext-dependent regulatory mechanisms control site-specific information processing within the MEK/ERK module
The impact of the cellular context and receptor type on the dynamics of phosphorylation cycles in signaling pathways are unclear. We employ an unbiased approach to identify network alterations that explain phosphorylation dynamics of the MEK/ERK module in response to hepatocyte growth factor or inte...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080803 | MassIVE
ProteomicsSuper-paramagnetic iron oxide nanoparticles reprogram the tumor microenvironment and reduce lung cancer growth
Tumor associated macrophages (TAMs) are known to play a role in a multitude of processes that facilitate lung cancer growth, including the suppression of tumoricidal immune activation and the absorption of chemotherapeutics. Therefore, deciphering new therapies to reprogram TAMs towards an anti-tumo...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-18 | PXD040145 | Pride
Macrophages Immunotherapy Spion Iron Lung cancer 
ModelsKok2020 - IFNalpha-induced signaling in Huh7.5 cells
The proposed ODE model describes dynamics of IFNalpha-induced signaling in Huh7.5 cells for a time scale up to 32 hours after stimulation with IFNalpha. The model consists of an IFN receptor model, formation/degradation and cytoplasmic/nuclear shuttling of STAT1-homodimers, STAT1-STAT2-heterodimers ...
2024-09-02 | BIOMD0000000959 | BioModels
ModelsBurbano2023 - HGFsignaling_in_FattyLiverDisease
Chronic liver diseases are worldwide on the rise. Due to the rapidly increasing incidence, in particular in Western countries, non-alcoholic fatty liver disease (NAFLD) is gaining importance. As the disease progresses it can develop into hepatocellular carcinoma. Lipid accumulation in hepatocytes ha...
2025-03-24 | BIOMD0000001102 | BioModels
ModelsZeilfelder2025 - Model for human liver cancer cell line HepG2
Mathematical multi-compartment model described by sets of coupled ordinary differential equations (ODEs) for studying the IL6 and SMAD signaling in HepG2 human cancer cell lines.
2025-11-13 | MODEL2503270001 | BioModels
ModelsZeilfelder2025 - Model for primary human hepatocytes (PHH)
Mathematical multi-compartment model described by sets of coupled ordinary differential equations (ODEs) for studying the IL6 and SMAD signaling in PHH cells.
2025-11-13 | MODEL2503270002 | BioModels
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