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TranscriptomicsGenome-Wide Specificity of DNA-Binding, Gene Regulation, and Chromatin Remodeling by TALE- and CRISPR/Cas9-Based Transcription Factors
Synthetic DNA-binding proteins have found broad application in gene therapies and as tools for interrogating biology. Engineered proteins based on the CRISPR/Cas9 and TALE systems have been used to alter genomic DNA sequences, control transcription of endogenous genes, and modify epigenetic states. ...
ORGANISM(S): Homo sapiens 
2015-05-27 | E-GEOD-68341 | biostudies-arrayexpress
GenomicsMultiple roles for Grainyhead-like transcription factors in the establishment and maintenance of human mucociliary airway epithelium (ChIP-Seq)
The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ basal cells. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evid...
ORGANISM(S): Homo sapiens 
2013-05-07 | E-GEOD-46194 | biostudies-arrayexpress
TranscriptomicsMultiple roles for Grainyheadlike transcription factors in the establishment and maintenance of human mucociliary airway epithelium
The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ basal cells. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evid...
ORGANISM(S): Homo sapiens 
2013-05-07 | E-GEOD-44718 | biostudies-arrayexpress
GenomicsDirect GR binding sites potentiate clusters of TF binding across the human genome
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-79432 | biostudies-arrayexpress
TranscriptomicsEnhanced MyoD-Induced Transdifferentiation to a Myogenic Lineage by Fusion to a Potent Transactivation Domain
Synthetic transcription factors can be applied to many areas of biotechnology, medicine, and basic research.  Currently, the most common method for engineering synthetic transcription factors has been based on programmable DNA-binding domains of zinc finger proteins, Transcription Activator-Like Ef...
ORGANISM(S): Homo sapiens 
2014-12-11 | E-GEOD-62448 | biostudies-arrayexpress
GenomicsDirect GR binding sites potentiate clusters of TF binding across the human genome [6]
The glucocorticoid receptor (GR) binds the human genome at >10,000 sites, but only regulates the expression of hundreds of genes. To determine the functional effect of each site, we measured the glucocorticoid (GC) responsive activity of nearly all GR binding sites (GBSs) captured using chromatin im...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-79429 | biostudies-arrayexpress
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