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TranscriptomicsDNA methylation profiling of male human pancreatic islets identifies loci for type 2 diabetes
Little is known about the contribution of the epigenome to the pathophysiology of type 2 diabetes (T2D). Here we have used genome-wide DNA methylation profiling to obtain the first comprehensive DNA methylation data set for human T2D pancreatic islets. Therefore, we analyzed the methylation profile ...
ORGANISM(S): Homo sapiens 
2012-04-22 | E-GEOD-21232 | biostudies-arrayexpress
UnknownBRCA1/2 Mutations and Bevacizumab in the Neoadjuvant Treatment of Breast Cancer: Response and Prognosis Results in Patients With Triple-Negative Breast Cancer From the GeparQuinto Study.
Not available
S-EPMC6067803 | biostudies-literature
UnknownA Clinically Relevant Gene Signature in Triple-Negative and Basal-Like Breast Cancer
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-31519 | biostudies-other
TranscriptomicsEpigenome analysis of genomic DNA isolated from whole blood of non-diabetic control and type-2 diabetic individuals
DNA methylation profiling of whole blood using Illumina's Infinium HumanMethylation27 Beadchip array. The dataset encompasses profiles of 12 non-diabetic control blood donors and 12 type-2 diabetic (T2D) individuals. Bisulfite converted DNA from 24 blood samples were hybridised to the Illumina Infin...
ORGANISM(S): Homo sapiens 
2012-04-22 | E-GEOD-34008 | biostudies-arrayexpress
TranscriptomicsA Clinically Relevant Gene Signature in Triple-Negative and Basal-Like Breast Cancer
Current prognostic gene expression profiles for breast cancer mainly reflect proliferation status and are most useful in ER-positive cancers. Triple-negative breast cancers (TNBCs) are clinically heterogeneous, and prognostic markers and biology-based therapies are needed to better treat this diseas...
ORGANISM(S): Homo sapiens 
2011-09-12 | E-GEOD-31519 | biostudies-arrayexpress
GenomicsTET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS
TET proteins convert 5-methylcytosine to 5-hydroxymethylcytosine, an emerging dynamic epigenetic state of DNA that can influence transcription. Evidence has linked TET1 function to epigenetic repression complexes, yet mechanistic information, especially for the TET2 and TET3 proteins, remains limite...
ORGANISM(S): Mus musculus 
2013-02-07 | E-GEOD-36620 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-HIPO-04-02-2020-14:25:47:776-113 - samples
This dataset contains 3 pairs of exomes, germline (from whole blood) and patient-derived xenograft (PDX), from human pancreatic durctal adenocarcinoma patients. The data is referred to in the publication: "Pro-immunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory a...
EGAD00001005938 | EGA
Genomicspancreatic ductal adenocarcinoma exomes in study: Pro-immunogenic Impact of MEK inhibition combined with an anti-CD40 immunostimulatory antibody
Cancer types with lower mutational load and a non-permissive tumor microenvironment are intrinsically resistant to immune checkpoint blockade. While the combination of cytostatic drugs and immunostimulatory antibodies constitutes an attractive concept for overcoming this refractoriness, suppression ...
EGAS00001004196 | EGA
GenomicsEGAS00000000046-ega-20110530 - samples
ICGC Germany PedBrain Medulloblastoma Pilot_2_LM
EGAD00001000027 | EGA
GenomicsLinking genes, genomic instability and molecular subgroups in medulloblastoma
Brain tumors are the second most common pediatric cancer and carry the highest mortality rates in this age group. Medulloblastoma is the most frequent malignant brain tumor of childhood. Recent studies indicate that medulloblastoma comprises at least four sub-entities (SHH-signaling, WNT-signali...
EGAS00001000085 | EGA
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