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UnknownCombined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia.
Not available
S-EPMC6404304 | biostudies-literature
UnknownE2F1 promotes angiogenesis through the VEGF-C/VEGFR-3 axis in a feedback loop for cooperative induction of PDGF-B.
Not available
S-EPMC3888194 | biostudies-literature
UnknownDecitabine demonstrates antileukemic activity in B cell precursor acute lymphoblastic leukemia with MLL rearrangements.
Not available
S-EPMC5936021 | biostudies-literature
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
ProteomicsNeocarzilin A is a potent inhibitor of cancer cell motility targeting VAT-1 controlled pathways
The natural product neocarzilin A (NCA) was discovered decades ago and despite its potent cytotoxic effects no mode of action studies were performed up to date. Synthesis of neocarzilins A, B, C and a stereoisomer of NCA provided insights into structural preferences as well as access to probes for f...
ORGANISM(S): Homo sapiens (Human) 
2019-08-23 | PXD012952 | Pride
Tumor cell migration Natural compound Target identification Chemical proteomics 
UnknownA Sensitive LC-MS/MS Method for the Simultaneous Determination of Two Thia-Analogous Indirubin N-Glycosides and Indirubin-3'-Monoxime in Plasma and Cell Culture Medium.
Not available
S-EPMC9101087 | biostudies-literature
ProteomicsThe cytotoxic natural product vioprolide A targets nucleolar protein 14 essential for ribosome biogenesis
The cytotoxic and antifungal peptolides vioprolide A-D were discovered in 1996, however their mode-of-action has so far been unsolved. Anti-cancer effect of the most potent cytotoxic derivative vioprolide A (VioA) were evaluated, showing a prominent potency against human acute lymphoblastic leukemia...
ORGANISM(S): Homo sapiens (Human) 
2020-01-13 | PXD015196 | Pride
Natural product Afbpp Lc-ms Target identification Thermal proteome profiling Co-ip 
UnknownTargeting TPC2 sensitizes acute lymphoblastic leukemia cells to chemotherapeutics by impairing lysosomal function.
Not available
S-EPMC9343397 | biostudies-literature
Unknown[Current questions regarding Covid-19 vaccination for specific populations - an overview of the state of research].
Not available
S-EPMC8007650 | biostudies-literature
UnknownOxytocin effects on experimental skin wound healing.
Not available
S-EPMC6754027 | biostudies-literature
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