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ProteomicsVon Willebrand factor A1 domain affinity for GPIbα and stability are differentially regulated by its O-glycosylated N-linker and C-linker
Hemostasis in the arterial circulation is mediated by binding of the A1 domain of the ultralong protein von Willebrand factor to GPIbα on platelets to form a platelet plug. A1 is activated by tensile force on VWF concatemers imparted by hydrodynamic drag force. The A1 core is protected from force-in...
ORGANISM(S): Homo sapiens (Human) 
2022-05-09 | PXD029942 | Pride
Mucin Protein stability Hdxms Von willebrand factor Conformational change Glycoprotein Hydrogen deuterium exchange Intrinsically disordered protein 
UnknownNatural variants of von Willebrand factor R1205 causing von Willebrand disease with accelerated von Willebrand factor clearance: In silico docking models and energetics of the interaction with both LRP1 and GpIb A1 domain.
Not available
S-EPMC12711066 | biostudies-literature
UnknownData on the purification and crystallization of the loss-of-function von Willebrand disease variant (p.Gly1324Ser) of the von Willebrand factor A1 domain.
Not available
S-EPMC5063811 | biostudies-literature
UnknownAn apparently silent nucleotide substitution (c.7056C>T) in the von Willebrand factor gene is responsible for type 1 von Willebrand disease.
Not available
S-EPMC3105650 | biostudies-literature
UnknownDeep molecular modeling and mechanistic insights into type 2A von Willebrand disease with von Willebrand factor A2 domain mutations.
Not available
S-EPMC12657285 | biostudies-literature
UnknownEvidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease.
Not available
S-EPMC7028320 | biostudies-literature
UnknownA discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor.
Not available
S-EPMC5585049 | biostudies-literature
UnknownLigand binding characteristics of the Ku80 von Willebrand domain.
Not available
S-EPMC7495496 | biostudies-literature
UnknownMechanisms by which von Willebrand disease mutations destabilize the A2 domain.
Not available
S-EPMC3585066 | biostudies-literature
UnknownA common mechanism by which type 2A von Willebrand disease mutations enhance ADAMTS13 proteolysis revealed with a von Willebrand factor A2 domain FRET construct.
Not available
S-EPMC5706690 | biostudies-literature
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