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ProteomicsHDX-MS Analysis of VPS13C-dATG2C-3xFLAG-CaM +/- Calcium
We carried out HDX-MS experiments on two conditions, VPS13C(dATG2C)-3xFLAG + EGTA, and VPS13C(dATG2C)-3xFLAG + Ca2+ to define conformational changes accompanying Ca2+. We saw an overall 69.7% coverage of VPS13C(dATG2C)-3xFLAG with 424 peptides identified and 66.4% coverage of CaM with 16 peptides id...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD076522 | Pride
GenomicsEffect of depletion of vacuolar protein sorting 13 homolog c (Vps13c) in heart tissue from ventricles of wild-type (WT) and cardiac-specific knockout (Vps13c-cKO) mice.
Effect of depletion of vacuolar protein sorting 13 homolog c (Vps13c) in heart tissue from ventricles of wild-type (WT) and cardiac-specific knockout (Vps13c-cKO) mice.
PRJNA1315041 | ENA
TranscriptomicsEffect of depletion of vacuolar protein sorting 13 homolog c (Vps13c) in heart tissue from ventricles of wild-type (WT) and cardiac-specific knockout (Vps13c-cKO) mice.
Systems genetics strategy across multiple Hybrid Mouse Diversity Panel (HMDP) cohorts pinpointed vacuolar protein sorting 13 homolog c (Vps13c) as a candidate trans-regulator of the mitochondrial transcriptome. Subsequent functional studies revealed that VPS13C influences mitochondrial morphology, b...
ORGANISM(S): Mus musculus 
2025-09-09 | GSE307260 | GEO
ProteomicsVPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are frequently linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...
ORGANISM(S): Homo sapiens (Human) 
2026-07-13 | PXD069825 | Pride
Human Lysosomal repair Vps13c Lysosome purification 
MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
GenomicsDownregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1
Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1
PRJNA985752 | ENA
GenomicsDownregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1 [SiHa]
Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1 [SiHa]
PRJNA986107 | ENA
UnknownVPS13A and VPS13C Influence Lipid Droplet Abundance.
Not available
S-EPMC9491623 | biostudies-literature
GenomicsDefect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice
Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice
PRJNA1262358 | ENA
UnknownVPS13C regulates phospho-Rab10-mediated lysosomal function in human dopaminergic neurons.
Not available
S-EPMC10868123 | biostudies-literature
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