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TranscriptomicsSmoking Status Impacts microRNA Mediated Prognosis and Lung Adenocarcinoma Biology
Cigarette smoke is associated with the majority of lung cancers: however, 25% of lung cancer patients are non-smokers, and half of all newly diagnosed lung cancer patients are former smokers. Lung tumors exhibit distinct epidemiological, clinical, pathological, and molecular features depending on sm...
ORGANISM(S): Homo sapiens 
2014-10-30 | E-GEOD-62182 | biostudies-arrayexpress
TranscriptomicsMethylation profiles of COPD small airways
Rationale: DNA methylation is an epigenetic modification that is highly disrupted in response to cigarette smoke and involved in a wide spectrum of malignant and non-malignant diseases, but surprisingly not previously assessed in small airways of patients with chronic obstructive pulmonary disease (...
ORGANISM(S): Homo sapiens 
2014-02-28 | E-GEOD-55454 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of COPD and nonCOPD small airway epithelia
Gene expression profiles in this submission were part of an integrative DNA methylation and gene expression integrative study. The goal of this study was to determine whether DNA methylation patterns were disrupted in small airway epithelia of patients with Chronic Obstructive Pulmonary Disease (COP...
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-56341 | biostudies-arrayexpress
TranscriptomicsMicrotubule Affinity-Regulating Kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.
MARK2 expression is associated with the malignant phenotype, expression of DNA repair components, NF-κB inhibition and cell cycle transcription factors in lung cancer cells We used microarrays to determine the global gene expression pattern associated with knockdown of MARK2 3 lung cancer cell lines...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-57966 | biostudies-arrayexpress
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