Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Microtubule Affinity-Regulating Kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.

ABSTRACT: MARK2 expression is associated with the malignant phenotype, expression of DNA repair components, NF-κB inhibition and cell cycle transcription factors in lung cancer cells We used microarrays to determine the global gene expression pattern associated with knockdown of MARK2 3 lung cancer cell lines overexpressing MARK2 have been selected to assess the gene expression pattern after MARK2 knockdown. RNA extraction and hybridization on Affymetrix microarrays have been done on 2 biological replicates for each line (H1993, H1693 and H1650) after shRNA lentiviral transduction and compared with respective contols using the empty vector pLKO.

ORGANISM(S): Homo sapiens

SUBMITTER: Roland Hubaux 

PROVIDER: E-GEOD-57966 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.

Hubaux Roland R   Thu Kelsie L KL   Vucic Emily A EA   Pikor Larissa A LA   Kung Sonia H Y SH   Martinez Victor D VD   Mosslemi Mitra M   Becker-Santos Daiana D DD   Gazdar Adi F AF   Lam Stephen S   Lam Wan L WL  

International journal of cancer 20150506 9

Microtubule affinity-regulating kinases (MARKs) are involved in several cellular functions but few studies have correlated MARK kinase expression with cancer, and none have explored their role in lung cancer. In this study, we identified MARK2 as frequently disrupted by DNA hypomethylation and copy gain, resulting in concordant overexpression in independent lung tumor cohorts and we demonstrate a role for MARK2 in lung tumor biology. Manipulation of MARK2 in lung cell lines revealed its involvem  ...[more]

Similar Datasets

Transcriptomics Microtubule Affinity-Regulating Kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.
2015-06-22 | GSE57966 | GEO
Transcriptomics Jinfukang enhances the pro-apoptotic activity of cisplatin via activation of AIFM2 in human lung cancer cells
2016-09-30 | E-MTAB-4671 | biostudies-arrayexpress
Genomics microRNA Expression data from Lung cancer cell lines
2019-01-23 | GSE125018 | GEO
Transcriptomics Expression data from Colossolactone H treated H1650 cells
2016-06-10 | E-GEOD-83161 | biostudies-arrayexpress
Transcriptomics Human tongue squamous cell carcinoma cell line SAS-Control vs. SAS-LYRIC knockdown stable clones global gene profiling
2016-02-28 | GSE44766 | GEO
Transcriptomics Expression data from Colossolactone H treated H1650 cells
2016-06-10 | GSE83161 | GEO
Transcriptomics The histone lysine demethylase Kdm6b is required for activity-dependent preconditioning of hippocampal neuronal survival
2014-06-12 | E-GEOD-58398 | biostudies-arrayexpress
Transcriptomics RNA seq to compare gene expression profiles between Npm1 WT and Npm1 knockdown cells
2020-06-22 | GSE133555 | GEO
Transcriptomics RNA sequencing of AHNAK2 knockdown adenocarcinoma cells compared with the scramble controls
2021-07-16 | GSE179982 | GEO
Transcriptomics Human tongue squamous cell carcinoma cell line SAS-Control vs. SAS-LYRIC knockdown stable clones global gene profiling
2016-02-28 | E-GEOD-44766 | biostudies-arrayexpress