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TranscriptomicsMetastatic breast cancer to the brain: set 1
Background: Metastases to the brain from breast cancer have a high mortality. Basal-like and HER2 positive breast cancers appear to have a high propensity to spread to the brain. The mechanisms that allow cells to colonise the brain are unclear. Methods: We have analysed matched and unpaired samples...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-14682 | biostudies-arrayexpress
TranscriptomicsThe application of nonsense-mediated mRNA decay inhibition to the identification of breast cancer susceptibility genes
Identification of novel, highly penetrant, breast cancer susceptibility genes will require the application of additional strategies beyond that of traditional linkage and candidate gene approaches. Approximately one-third of inherited genetic diseases, including breast cancer susceptibility, are cau...
ORGANISM(S): Homo sapiens 
2012-04-11 | E-GEOD-37210 | biostudies-arrayexpress
TranscriptomicsEvaluating the restoration of DNA derived from archival formalin-fixed paraffin embedded tissues for genomic profiling by SNP-CGH analysis
Pathology archives contain vast resources of clinical material in the form of formalin-fixed paraffin embedded (FFPE) tissue samples. Due to the methods of tissue fixation and storage, the integrity of DNA and RNA available from FFPE tissue is compromised, meaning obtaining informative data regardin...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-43406 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma (PDAC)
Determine methylation pattern in PDAC a genome-wide analysis was performed in a cohort of 167 PDAC and 29 adjacent pancreatic tissues samples using the Infinium 450k methylation arrays (Illumina). 167 pancreatic tumors (PDAC) x 29 adjacent -non tumor samples.
ORGANISM(S): Homo sapiens 
2014-07-08 | E-GEOD-49149 | biostudies-arrayexpress
TranscriptomicsICGC Pancreas: Genomewide DNA methylation patterns in pancreatic ductal adenocarcinoma (gene expression of 103 samples)
Epigenetic modifications, particularly DNA methylation have been increasingly implicated in cancer. Although some genes display aberrant methylation in pancreatic cancer, a comprehensive global analysis is yet to be performed. To define the genome-wide pattern of DNA methylation in pancreatic ductal...
ORGANISM(S): Homo sapiens 
2014-05-05 | E-GEOD-50827 | biostudies-arrayexpress
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