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TranscriptomicsIdentification of metastamirs as metastasis-associated microRNAs in clear cell renal cell carcinomas
Background/Objective: MicroRNAs (miRNAs) play a pivotal role in cancerogenesis and cancer progression, but their specific role in metastasis of clear cell renal cell carcinomas (ccRCCs) as so-called metastamirs is still limited. Based on microRNA microarray analyses from normal (n=12) and cancerous ...
ORGANISM(S): Homo sapiens 
2013-02-26 | E-GEOD-37989 | biostudies-arrayexpress
TranscriptomicsGenome-scale RNAi profiling of cell division in human tissue culture cells
Cell division is a fundamental process for multicellula organisation. Here we report a genome-scale RNAi screen in HeLa cells designed to identify human genes important for cell division. We utilized a library of endoribonuclease-prepared siRNAs (esiRNAs) for gene-silencing and used DNA content an...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9176 | biostudies-arrayexpress
TranscriptomicsCell-density resolved comparative analysis of D. shibae wild-type vs. delta-luxI1 overexpressing luxI1 in trans
D. shibae delta-luxI1 overexpressing the luxI1 gene in trans was compared to the wild-type in order to identify quorum sensing controlled traits in this organism. Samples were taken at different optical densities in the exponential phase and in the stationary phase. Samples from Dinoroseobacter shib...
ORGANISM(S): Dinoroseobacter shibae DFL 12 
2012-11-03 | E-GEOD-42012 | biostudies-arrayexpress
TranscriptomicsCell-density resolved comparative analysis of D. shibae wild-type vs. delta-luxI1
A quorum sensing null mutant was compared with D. shibae wild-type in order to identify quorum sensing controlled traits in this organism. Samples were taken at different optical densities in the exponential phase and in the stationary phase in order to clarify if quorum sensing regulation is depend...
ORGANISM(S): Dinoroseobacter shibae DFL 12 
2012-11-03 | E-GEOD-42011 | biostudies-arrayexpress
TranscriptomicsComparative analysis of D. shibae wild-type vs. delta-luxI1 supplemented with different acetylated homoserine-lactones
Comparison of a quorum sensing null mutant supplemented with C18-HSL, C18en-HSL, C18dien-HSL with D. shibae wild-type in order to identify traits induced by distinct autoinducers in this organism. Loop-design, two to three biological replicates of D. shibae wild-type, delta-luxI1 and delta-luxI1 sup...
ORGANISM(S): Dinoroseobacter shibae DFL 12 
2012-11-03 | E-GEOD-42010 | biostudies-arrayexpress
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