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Recent observations show that the single-cell response of p53 to ionizing radiation (IR) is “digital” in that it is the number of oscillations rather than the amplitude of p53 that shows dependence on the radiation dose. We present a model of this phenomenon. In our model, double-strand break (DSB) ...
2020-05-13 | MODEL2005130001 | BioModels
The membrane-integrated metallo-protease FtsH11 of Arabidopsis thaliana is proposed to be dual targeted to mitochondria and chloroplasts. A bleached phenotype was observed in ftsh11 grown at long days or continuous light, pointing to disturbances in the chloroplast. Under these growth conditions the...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-03-03 | PXD002969 | Pride
This study provides insights into the efficacy of beta-blockers as breast cancer therapeutics.Cell line models of basal-type and estrogen receptor-positive breast cancer were profiled for basal levels of adrenoceptor gene/protein expression, and ADRβ2-mediated cell behaviour including migration, inv...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD009488 | Pride
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