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UnknownRedistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer.
Not available
S-EPMC4268254 | biostudies-literature
TranscriptomicsBurkitt Lymphoma Pathogenesis and Therapeutic Targets from Structural and Functional Genomics
Burkitt lymphoma (BL) can often be cured by intensive chemotherapy, but the toxicity of such therapy precludes its use in the elderly and in patients with endemic BL (eBL) in developing countries, necessitating new strategies. The normal germinal center B cell is the presumed cell of origin for both...
ORGANISM(S): Homo sapiens 
2012-08-16 | E-GEOD-35163 | biostudies-arrayexpress
TranscriptomicsInduction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells
The mechanism whereby IL-9 stimulated monocytes, promote proliferation of co-cultured ATL cells remains undefined. To obtain preliminary clues concerning this contribution, transcription profiles were obtained between monocytes derived from ATL patients and those derived from healthy donors as asses...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-10789 | biostudies-arrayexpress
UnknownEnhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia.
Not available
S-EPMC7585144 | biostudies-literature
TranscriptomicsMurine CD8+ Pmel Lymphocytes IL-2 vs. IL-15
Central memory tumor-reactive CD8+ T cells confer superior antitumor immunity compared to effector memory T cells
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2578 | biostudies-arrayexpress
UnknownCP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.
Not available
S-EPMC3056641 | biostudies-literature
GenomicsRegulating Interleukin-2 activity with engineered receptor signaling clamps
Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits. Previously, we engineered an IL-2 “superkine” (H9) with enhanced affinity for IL-2Rβ. Here, we describe next-generation IL-2 variants that...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-64713 | biostudies-arrayexpress
UnknownEffective treatment with the selective cytokine inhibitor BNZ-1 reveals the cytokine dependency of T-LGL leukemia.
Not available
S-EPMC10613725 | biostudies-literature
UnknownA novel model of alternative NF-κB pathway activation in anaplastic large cell lymphoma.
Not available
S-EPMC9245089 | biostudies-literature
UnknownTriple combination of BET plus PI3K and NF-κB inhibitors exhibit synergistic activity in adult T-cell leukemia/lymphoma.
Not available
S-EPMC9006306 | biostudies-literature
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