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TranscriptomicsLong-term culture associated gene expression changes in MSC (TGFb treatment)
Mesenchymal stromal cells (MSC) were isolated from human bone marrow. Here, we have compared gene expression profiles of MSC at early and late passages and upon stimulation with transforming growth factor beta 1 (TGF-b1). Stimulation was performed with 1ng/mL TGF-b1 for 1, 4, or 12 hours as indicate...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-46019 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for different passages of mesenchymal stem cells.
Cells in culture undergo replicative senescence and unequivocally stop proliferation after a limited number of cell divisions. In this study, we have expanded mesenchymal stem cells (MSC) from human adipose tissue and analyzed genetic and epigenetic sequels. The subpopulation of highly proliferative...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-27135 | biostudies-arrayexpress
TranscriptomicsReplicative senescence of mesenchymal stem cells causes DNA methylation changes which correlate with repressive histone marks
Cells in culture undergo replicative senescence. In this study, we analyzed functional, genetic and epigenetic sequels of long‐term culture in human mesenchymal stem cells (MSC). Already within early passages the fibroblastoid colony‐ forming unit (CFU‐f) frequency and the differentiation potential ...
ORGANISM(S): Homo sapiens 
2011-10-27 | E-GEOD-26519 | biostudies-arrayexpress
TranscriptomicsPluripotent Stem Cells Escape From Senescence-Associated DNA Methylation Changes [Illumina]
Pluripotent stem cells evade replicative senescence, whereas other primary cells lose their proliferation and differentiation potential after a limited number of cell divisions M-bM-^@M-^S and this is accompanied by specific senescence-associated DNA methylation (SA-DNAm) changes. Here, we investiga...
ORGANISM(S): Homo sapiens 
2012-09-24 | E-GEOD-37066 | biostudies-arrayexpress
TranscriptomicsPluripotent Stem Cells Escape From Senescence-Associated DNA Methylation Changes
This SuperSeries is composed of the following subset Series: GSE37065: Long-term culture associated gene expression changes in MSC [Affymetrix] GSE37066: Pluripotent Stem Cells Escape From Senescence-Associated DNA Methylation Changes [Illumina] GSE38806: Gene expression profiles of induced pluripot...
ORGANISM(S): Homo sapiens 
2012-09-24 | E-GEOD-37067 | biostudies-arrayexpress
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