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TranscriptomicsTranscriptome profiling reveals a novel role for Trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti-silencing.
The histone chaperones play an important role in chromatin assembly and disassembly during replication and transcription. We assessed the global roles of histone chaperones in Saccharomyces cerevisiae. Microarray transcriptional analyses indicate that histone chaperones have their own specific targe...
ORGANISM(S): Saccharomyces cerevisiae 
2011-06-28 | E-GEOD-30228 | biostudies-arrayexpress
TranscriptomicsEnvironment-responsive transcription factors bind proto-silencer elements and regulate subtelomeric silencing
Subtelomeric chromatin is subject to evolutionarily conserved complex epigenetic regulation and is implicated in numerous aspects of cellular function including formation of heterochromatin, regulation of different stress response pathways, and control of lifespan. Subtelomeric DNA is characterized...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-02 | E-GEOD-21852 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of yeast transcription factor deletion strains (rox1, xbp1 or phd1) and wild-type strains in response to hydrogen peroxide or butanol
The goal of this study was to determine the effect of transcription factor deletions on the expression of subtelomeric genes in the presence of environmental stimuli. This study is a component of a larger study, which identified that environment-responsive transcription factors bind proto-silencer e...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-16 | E-GEOD-21926 | biostudies-arrayexpress
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