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ProteomicsTunable activated esters for lysine labeling in proteome
The development of various heteroaromatic activated esters designed for selective lysine labeling within the proteome for profiling purposes. Through systematic optimization of the reactivity and selectivity of these esters, we identified a series of effective probe molecules suitable for both in vi...
ORGANISM(S): Homo Sapiens 
PXD051323 |
ProteomicsPTMC_The proteomic profiles of pyridinium-based strategy for lysine-selective protein modification in live cells
A new bioorthogonal lysine-labeling strategy based on cationic-pyridinium activated ester, which renders the modification of peptides and proteins’ lysine residues with ultrafast kinetics and excellent specificity under aqueous solution, and profiled reactive-lysine proteome in vitro and in live cel...
ORGANISM(S): Homo Sapiens 
PXD036388 |
ProteomicsPTMC_A pyridinium-based strategy for bioorthogonal conjugation-assisted purification method for profiling cell surface proteome
Cell surface proteins (CSPs) are valuable targets for therapeutic agents, but achieving highly selective CSP enrichment in cellular physiology remains a technical challenge. To address this challenge, we propose a newly developed sulfo-pyridinium-ester (SPE) cross-linking probe, followed by two-step...
ORGANISM(S): Homo Sapiens 
PXD044541 |
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