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ProteomicsMulti-omics analysis of human peripheral blood reveals marked molecular profiling changes caused by one night of sleep deprivation
Sleep insufficiency is associated with various disorders (cardiovascular disease, neurodegenerative diseases, immunological disorders.) but the molecular bases for these associations are largely unknown. We used multiple omics techniques to examine changes in the blood of healthy male and female adu...
ORGANISM(S): Homo Sapiens 
2022-04-23 | PXD033402 |
ProteomicsPCK2-mediated PQBP1 lactylation promotes asthmatic inflammation through PRMT5 inhibition
Background: Asthma involves chronic inflammation linked to metabolic reprogramming, but how metabolites reshape epigenetics through post-translational modifications remains unclear. Methods: We used HDM-induced asthmatic mice with multi-omics analyses (metabolomics, PTM-proteomics, ChIP-seq) and val...
ORGANISM(S): Homo Sapiens 
2025-11-12 | PXD070618 |
ProteomicsA phosphorylation-dependent ubiquitination switch orchestrates nuclear immune reprogramming upon chitin perception
OsRLCK185 is a functional kinase, we then examined whether OsRLCK185 phosphorylates OsPUB20 using an in vitro kinase assay, OsRLCK185K108A served as a negative control. The results showed that GST-OsRLCK185, but not GST-OsRLCK185K108A, phosphorylates OsPUB20 in vitro. Using LC-MS/MS analysis after a...
ORGANISM(S): Oryza Sativa 
2026-01-29 | PXD073757 |
ProteomicsA phosphorylation-dependent ubiquitination switch orchestrates nuclear immune reprogramming
The nuclear localization of OsGF14f is crucial for blast resistance. To understand how OsGF14f functions in the nucleus to modulate blast resistance, we identified OsGF14f-interacting proteins by LC-MS/MS assays with OsGF14f-GFP plants. Among the candidate proteins, a nuclear-localized protein was O...
ORGANISM(S): Oryza Sativa 
2026-01-29 | PXD073756 |
ProteomicsPPTC7 integrates homeostatic and physiological signals to regulate mitophagy and mitochondrial mass
Here we report that knockout of PPTC7, a mitochondrial matrix protein, hyperactivates BNIP3/NIX-mediated mitophagy in vitro and in vivo. Biochemically, the PPTC7 precursor is trapped by BNIP3 and NIX to mitochondrial outer-membrane, where PPTC7 scaffolds the assembly of the substrate-PPTC7- SCFFBXL4...
ORGANISM(S): Homo Sapiens 
2023-06-05 | PXD042744 |
ProteomicsCopper exposure aggravates motor phenotype via inhibiting mitophagy in SOD1G93A transgenic mice
Background Amyotrophic lateral sclerosis (ALS) is an age-dependent and incurable neurodegenerative disease. It is pathologically characterized by selective degeneration of motor neurons resulting in a catastrophic loss of motor function. Previous studies showed that excess copper (Cu) might have a r...
ORGANISM(S): Mus Musculus 
2023-01-29 | PXD039728 |
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