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TranscriptomicsAmplification of RANK- and c-Met-mediated signaling promotes metastatic colonization
We found that RANKL, expressed by cancer cells or derived from exogenous sources, consistently induced human prostate, breast, kidney, lung and liver cancer cells to colonize or metastasize to bone in an animal model of cancer bone metastasis. RANK-mediated signaling established a premetastatic nich...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-48432 | biostudies-arrayexpress
UnknownCulicoides jiangchengensis, a new species of the subgenus Sinocoides (Diptera, Ceratopogonidae) based on integrative taxonomy from China.
Not available
S-EPMC10370730 | biostudies-literature
MetabolomicsDifferential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a ...
2022-11-15 | MTBLS2352 | MetaboLights
GenomicsPolycomb Protein Ezh1 Promotes RNA Polymerase II Elongation
Polycomb group (PcG) proteins initiate the formation of repressed chromatin domains and regulate developmental gene expression. A mammalian PcG protein, Enhancer of Zeste homolog 2 (Ezh2), triggers transcriptional repression by catalyzing the addition of methyl groups onto lysine-27 of histone H3 (...
ORGANISM(S): Mus musculus 
2011-11-23 | E-GEOD-25549 | biostudies-arrayexpress
TranscriptomicsNOT2 proteins promote Pol II-dependent transcription and interact with multiple miRNA biogenesis factors in Arabidopsis
MicroRNAs (miRNAs) play key regulatory roles in numerous developmental and physiological processes in animals and plants. The elaborate mechanism of miRNA biogenesis involves transcription and multiple processing steps. Here, we report the identification of a pair of evolutionarily conserved NOT2_3_...
ORGANISM(S): Arabidopsis thaliana 
2013-01-30 | E-GEOD-42901 | biostudies-arrayexpress
UnknownSex-Dependent Effects of Cadmium Exposure in Early Life on Gut Microbiota and Fat Accumulation in Mice.
Not available
S-EPMC5332190 | biostudies-literature
TranscriptomicsNew insight into a host-pathogen interaction unveiled by transcriptomics response of the global insect pest Plutella xylostella to a fungal pathogen
A genomic insight into how an insect pest responds to the infection of a fungal insect pathogen, such as Beauveria bassiana, is critical for alternative strategy of insect pest contol based on fungal insecticides but has not been well probed. Here we constructed three pairs of digital expression lib...
ORGANISM(S): Plutella xylostella 
2016-04-06 | E-GEOD-72383 | biostudies-arrayexpress
UnknownStudy on Extraction and Purification of Acanthopanax senticosus Polyphenols by an Ionic Liquid-Assisted Aqueous Two-Phase System.
Not available
S-EPMC10490139 | biostudies-literature
TranscriptomicsERβ activation by genistein promotes metastatic progression in prostate cancer
Androgen signalling through the androgen receptor (AR) plays a critical role in prostate cancer (PCa) initiation and progression. Estrogen and the estrogen receptor, in synergy with androgen, are essential for cell growth of the normal and malignant prostate. However, the exact role that estrogen pl...
ORGANISM(S): Homo sapiens 
2012-12-27 | E-GEOD-43146 | biostudies-arrayexpress
UnknownAssociations of Serum Cystatin C, DNAm Cystatin C, Renal Function, and Mortality in U.S. Adults.
Not available
S-EPMC11767232 | biostudies-literature
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