Sort   by:  
 Page size 
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
GenomicsMechanism of Ikaros tumor suppression in Leukemia
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-11-03 | E-GEOD-44218 | biostudies-arrayexpress
GenomicsMechanisms of Ikaros Tumor Suppression with HDAC1 through distinct histone markers in Pre-B ALL Leukemia
Ikaros functions as a master regulator of lymphocyte differentiation and a tumor suppressor. Ikaros binds DNA and regulates gene expression by chromatin remodeling. Mechanisms of Ikaros-mediated tumor suppression are unknown. Here we examined genome-wide occupancy of Ikaros and histone deacetylase 1...
ORGANISM(S): Homo sapiens 
2015-11-03 | E-GEOD-44217 | biostudies-arrayexpress
ProteomicsProteomics of human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles
MSC-EV exerts their effects by transferring cargo components into target cells. Given that extracellular vesicles (EV) can deliver diverse cargo to recipient cells and elicit similar therapeutic effects, we investigate the cargo of both adipose-derived MSC-derived EV (AMSC-EV) and umbilical cord-der...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056371 | Pride
Mesenchymal stem cell Extracellular vesicles Human 
TranscriptomicsMCF7 breast cancer cells treated with mesenchymal stem cell-derived exosomes
Human mesenchymal stem cell (MSC)-conditioned medium (CM) was previously reported to affect the biology of tumor cells; however, the precise mechanisms remain unclear. Here, we show that MSCs secreted 40- to 100-nm particles, which have the typical characteristics of exosomes, and these MSC-derived ...
ORGANISM(S): Homo sapiens 
2013-05-20 | E-GEOD-46950 | biostudies-arrayexpress
TranscriptomicsDDB2 regulates gene expression in ovarian cancer cell lines
DDB2 has been suggested to function as a transcription regulator in various cancer cell lines. We stably overexpressed DDB2 in ovarian cancer cell line A2780-CP70, and compared the gene expression profiles between DDB2-overexpressed and empty vector-transfected cells. Empty vector and DDB2-expressin...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-66636 | biostudies-arrayexpress
TranscriptomicssiRNA knockdown in human HEK293 cells transfected with siRNA specific for StarPap or PIPKIalpha or control siRNA
A loss of StarPap would be predicted to result in a decrease in cellular levels of mRNAs which it polyadenylates. Moreover, if PIPKIalpha has a function relationship with StarPap, knockdown of PIPKIalpha should cause a decrease in a pool of target mRNAs which require both StarPap and PIPKIalpha for...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-9361 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in Nalm6 ALL leukemia cells
Identify the expression intensity for all genes in Nalm6 cells and all the genes are divided into 4 equal groups with group 1 containing the 25% of genes that were expressed at the highest levels, and group 4 containing the 25% of genes that were expressed at the lowest levels. Total RNA are isolate...
ORGANISM(S): Homo sapiens 
2015-11-03 | E-GEOD-44214 | biostudies-arrayexpress
UnknownSoliton formation and spectral translation into visible on CMOS-compatible 4H-silicon-carbide-on-insulator platform.
Not available
S-EPMC9726892 | biostudies-literature
Sort   by:  
 Page size