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ProteomicsIn situ Analysis of Nanoparticle Soft Corona and Dynamic Evolution
How soft corona i.e., the protein corona’s outer layer contributes to “biological” identity of nanomaterials (NMs) is largely unknown due to a longstanding challenge in capturing protein composition of the soft corona in situ. We herein develop an in situ “Fishing” method that can monitor the dynami...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD033976 | Pride
Protein corona Mouse serum 
ProteomicsSelective Regulation of Macrophage Lipid Metabolism via Nanomaterials’ Surface Chemistry
Understanding the interfacial structure between nanomaterials and lipoproteins is crucial for gaining profound insights into how nanomaterials impact lipoprotein structure and interfere with lipid metabolism. In this study, we employed graphene oxide (GO) nanosheets (NSs) with precisely controlled s...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044475 | Pride
Human plasma Low density lipoprotein Lc-ms Lipid metabolism Graphene oxide Surface hydrophilicity 
UnknownOral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19.
Not available
S-EPMC11156186 | biostudies-literature
GenomicsHigh Density SNP Association Analysis of Melanoma: Case-Control and Outcomes Investigation

This research builds upon an extensive resource of melanoma cases and hospital based controls collected over several years at the U.T. M.D. Anderson Cancer Center. The goal of this research is to identify novel susceptibility and outcome-related genes for melanoma using a systematic genome-wide a...

phs000187.v1.p1 | EGA
TranscriptomicsAngiogenesis study of Gd@C82(OH)22 nanoparticle
we report a novel nanomedicine (Gd@C82(OH)22 ) effectively inhibit human breast tumor growth by antiangiogenesis in vivo. To further identify which angiogenic factor(s) were affected on mRNA level, the "RT² Profiler™ PCR Array Mouse Angiogenesis (APMM-024, SuperArray Bioscience Corporation)&qu...
ORGANISM(S): Mus musculus 
2009-04-01 | E-GEOD-7861 | biostudies-arrayexpress
MetabolomicsLimited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. In pancreatic cancer cells, a cytosolic metabolic enzyme, wild-type isocitrate dehydrogenase 1 (wtIDH1), enables the adaptation to these co...

2022-04-29 | MTBLS4722 | MetaboLights
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