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TranscriptomicsRole of the accessory gene regulator agr in community-associated MRSA pathogenesis
The success of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) as pathogens is due to a combination of antibiotic resistance with high virulence. However, evolution of the exceptional virulence potential of CA-MRSA is not understood. Our previous study indicated that diffe...
ORGANISM(S): Staphylococcus aureus 
2011-03-29 | E-GEOD-18793 | biostudies-arrayexpress
GenomicsGenome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3
We developed a system to study the DNA replication-independent turnover nucleosomes containing the histone variant H3.3 in mammalian cells. By measuring the genome-wide incorporation of H3.3 at different time points following epitope-tagged H3.3 expression, we find three categories of H3.3-nucleosom...
ORGANISM(S): Mus musculus 
2013-10-23 | E-GEOD-51505 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis 8 GFP marked lines with 2-3 replicates were used to augment existing microarray expression profiles of the root
Transcriptional programs that regulate development are exquisitely controlled in space and time. Elucidating these programs that underlie development is essential to understanding the acquisition of cell and tissue identity. We present microarray expression profiles of a high resolution set of deve...
ORGANISM(S): Arabidopsis thaliana 
2008-06-16 | E-GEOD-8934 | biostudies-arrayexpress
TranscriptomicsNormal Lung + Lung adenocarcinoma microarray
Gene transcription in a set of 49 human primary lung adenocarcinomas and 9 normal lung tissue samples was examined using Affymetrix GeneChip technology. We aimed to investigate differential gene expression between the two tissue types. A total of 3,442 genes, called the set MAD, were found to be eit...
ORGANISM(S): Homo sapiens 
2005-12-31 | E-MEXP-231 | biostudies-arrayexpress
TranscriptomicsMutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2 [04_Cerebellun_and_brain]
Senataxin, encoded by the SETX gene, contributes to multiple aspects of gene expression, including transcription and RNA processing. Mutations in SETX cause the recessive disorder ataxia with oculomotor apraxia type 2 (AOA2) and a dominant juvenile form of amyotrophic lateral sclerosis (ALS4). To as...
ORGANISM(S): Mus musculus 
2014-09-15 | E-GEOD-61324 | biostudies-arrayexpress
TranscriptomicsMutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2 [01_fibroblasts_patientAndcarrier]
Senataxin, encoded by the SETX gene, contributes to multiple aspects of gene expression, including transcription and RNA processing. Mutations in SETX cause the recessive disorder ataxia with oculomotor apraxia type 2 (AOA2) and a dominant juvenile form of amyotrophic lateral sclerosis (ALS4). To as...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-61320 | biostudies-arrayexpress
TranscriptomicsMutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2 [03_AOA2_patient_blood_2011]
Senataxin, encoded by the SETX gene, contributes to multiple aspects of gene expression, including transcription and RNA processing. Mutations in SETX cause the recessive disorder ataxia with oculomotor apraxia type 2 (AOA2) and a dominant juvenile form of amyotrophic lateral sclerosis (ALS4). To as...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-61322 | biostudies-arrayexpress
TranscriptomicsMutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2 [02_fibroblasts_transfected]
Senataxin, encoded by the SETX gene, contributes to multiple aspects of gene expression, including transcription and RNA processing. Mutations in SETX cause the recessive disorder ataxia with oculomotor apraxia type 2 (AOA2) and a dominant juvenile form of amyotrophic lateral sclerosis (ALS4). To as...
ORGANISM(S): Homo sapiens 
2014-09-15 | E-GEOD-61321 | biostudies-arrayexpress
TranscriptomicsDiscovery and validation of gene classifiers for endocrine disrupting chemicals in Zebrafish (Danio rerio)
Background: Development and application of transcriptomics-based gene classifiers for ecotoxicological applications lag far behind those of human biomedical science. Many such classifiers discovered thus far lack vigorous statistical and experimental validations, with their stability and reliabilit...
ORGANISM(S): Danio rerio 
2012-08-22 | E-GEOD-38070 | biostudies-arrayexpress
TranscriptomicsSarZ is a key regulator of biofilm formation and virulence in Staphylococcus epidermidis
Biofilm-associated infection by the leading nosocomial pathogen Staphylococcus epidermidis is a major problem for the public health system. Here we used an especially discriminatory, two-step screen to discover key biofilm factors. We identified the transcriptional regulator and SarA paralog SarZ as...
ORGANISM(S): Staphylococcus epidermidis 
2010-05-25 | E-GEOD-8523 | biostudies-arrayexpress
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