Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Normal Lung + Lung adenocarcinoma microarray

ABSTRACT: Gene transcription in a set of 49 human primary lung adenocarcinomas and 9 normal lung tissue samples was examined using Affymetrix GeneChip technology. We aimed to investigate differential gene expression between the two tissue types. A total of 3,442 genes, called the set MAD, were found to be either up- or down-regulated by at least two fold between the two phenotypes. Genes assigned to a particular gene ontology term were found, in many cases, to be significantly unevenly distributed between the genes in and outside MAD. Terms that were overrepresented in MAD included functions directly implicated in cancer cell metabolism. Based on their functional roles and expression profiles, genes in MAD were grouped into likely co-regulated gene sets.

ORGANISM(S): Homo sapiens

SUBMITTER: David Smith

PROVIDER: E-MEXP-231 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Conserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays.

Yap Yee Leng YL Lam David C L DC Luc Girard G Zhang Xue Wu XW Hernandez David D Gras Robin R Wang Elaine E Chiu S W SW Chung Lap Ping LP Lam W K WK Smith David K DK Minna John D JD Danchin Antoine A Wong Maria P MP

Nucleic acids research 20050114 1

Gene transcription in a set of 49 human primary lung adenocarcinomas and 9 normal lung tissue samples was examined using Affymetrix GeneChip technology. A total of 3442 genes, called the set M AD, were found to be either up- or down-regulated by at least 2-fold between the two phenotypes. Genes assigned to a particular gene ontology term were found, in many cases, to be significantly unevenly distributed between the genes in and outside M AD. Terms that were overrepresented in M AD included func ...[more]

PMID: 15653641

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Dataset Information

Normal Lung + Lung adenocarcinoma microarray

Publications

Conserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays.

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