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UnknownWhole Exome Sequencing Study Identifies Distinct Characteristics of Transformed Small Cell Lung Cancer With EGFR Mutation Compared to De Novo Small Cell and Primary Non-Small Cell Lung Cancers.
Not available
S-EPMC11976457 | biostudies-literature
UnknownIFN-α inhibits HBV transcription and replication by promoting HDAC3-mediated de-2-hydroxyisobutyrylation of histone H4K8 on HBV cccDNA minichromosome in liver.
Not available
S-EPMC9160025 | biostudies-literature
MetabolomicsMultiple acyl-coA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection

The human pathogen Mycobacterium tuberculosis (Mtb) devotes a significant fraction of its genome to fatty acid metabolism. Although Mtb depends on host fatty acids as a carbon source, fatty acid b-oxidation is mediated by genetically redundant enzymes, which has hampered the development of antitu...

2021-09-29 | MTBLS2374 | MetaboLights
ProteomicsTraceless peptide and protein modification via rational tuning of halopyridiniums
Building on the insights gained from systematically investigating of aromatic nucleophilic substitution (SNAr) and thiol-exchange, we identified the highly electron-deficient halopyridiniums as a tunable and predictable reaction platform for adjusting electrophilicity and thiol-cleavability by follo...
ORGANISM(S): Homo Sapiens 
2023-09-25 | PXD045683 |
TranscriptomicsTranscriptome study in rhesus monkey
Rhesus Monkey is one of the important primate models widely used in the fields of disease mechanism study, pre-clinical test in drug discovery and molecular evolution. However, the majority of rhesus gene annotations were putatively mapped from human genome, with only 10% supported by rhesus EST dat...
ORGANISM(S): Macaca mulatta 
2012-10-10 | E-GEOD-34426 | biostudies-arrayexpress
ProteomicsThe de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging
In the era of synthetic biology, design, construction, and utilization of synthetic chromosomes with unique features provide a new strategy to study complex cellular processes such as aging. Herein, we successfully constructed the 884 Kb synXIII of Saccharomyces cerevisiae to investigate replicative...
ORGANISM(S): Saccharomyces Cerevisiae 
2024-10-30 | PXD057330 |
UnknownProtective Effects of Scutellarin on Human Cardiac Microvascular Endothelial Cells against Hypoxia-Reoxygenation Injury and Its Possible Target-Related Proteins.
Not available
S-EPMC4628680 | biostudies-literature
UnknownTranscriptome Profiling Analysis of Wolf Spider Pardosa pseudoannulata (Araneae: Lycosidae) after Cadmium Exposure.
Not available
S-EPMC5187833 | biostudies-literature
UnknownIFN-α confers epigenetic regulation of HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA.
Not available
S-EPMC7487718 | biostudies-literature
GenomicsChIPseq examination of EAP-1 binding across generations of spr-5(by101) mutant worms
How epigenetic information is transmitted from generation to generation remains largely unknown. Deletion of the C. elegans Histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-5 leads to inherited accumulation of the euchromatic H3K4me2 mark and progressive decline in fertility. Here we identifie...
ORGANISM(S): Caenorhabditis elegans 
2014-04-08 | E-GEOD-52102 | biostudies-arrayexpress
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