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MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
ProteomicsSAPT, a fast and efficient approach for simultaneous profiling of protein N- and C-terminome
Protein termini play pivotal roles in various biological processes. Although a series of terminomic strategies have been proposed for the analysis of protein N-termini or protein C-termini separately, few can analyze both ends of proteins at the same time. Herein, we developed a workflow, termed Sim...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD024573 | Pride
Human Protein termini Hela cell 
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
ProteomicsIntensive lifestyle intervention modulates white adipose glycolipid metabolism via protein acetylation associated with Ep300
The homeostatic regulation of white adipose tissue (WAT) is crucial for maintain energy and metabolism balance. Plenty of clinical trials proved that intensive lifestyle intervention (ILI) improved fat accumulation in patients with obesity. Yet the underlying acetylated regulations of WAT during ILI...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-02 | PXD046768 | Pride
White adipose tissue  acetylation modification  obesity  intensive lifestyle intervention  ep300 
TranscriptomicsEffects of Brca1 knock-down on Ezh2 targeting
The Polycomb repressive complex 2 (PRC2) is important for the maintenance of stem cell pluripotency and suppression of cell differentiation by promoting histone H3 lysine 27 trimethylation (H3K27me3) and silencing expression of genes regulating differentiation. Here we show decreased expression of B...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-37321 | biostudies-arrayexpress
UnknownThe therapeutic effects of human embryonic stem cells-derived immunity-and-matrix regulatory cells on membranous nephropathy.
Not available
S-EPMC9172125 | biostudies-literature
TranscriptomicsExpression data from MCF-7 and MCF-7/ADR cells
Chemoresistance in breast cancer has been a great interest in past studies, however, the development of rational therapeutic strategies targeting chemoresistant cells is still a challenge for clinical oncology.The resistant property of MCF7/ADR cells was confirmed by long term culture with Dox, cell...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-76540 | biostudies-arrayexpress
ProteomicsUltrafast and Chemoselective Biotinylation of Living Cell Surface for Time-Resolved Surfaceome Analysis - final
Cell surface proteins participate in many important biological processes such as cell-to-cell interaction, signal transduction, cell adhesion, and protein transportation. In-depth study of the cell surface protein group is of great significance. Nevertheless, detection and analysis of the surfaceome...
ORGANISM(S): Homo Sapiens 
2024-07-06 | PXD053733 |
UnknownAllogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial.
Not available
S-EPMC6042450 | biostudies-literature
UnknownComparative analysis of mesenchymal stem cells derived from amniotic membrane, umbilical cord, and chorionic plate under serum-free condition.
Not available
S-EPMC6330472 | biostudies-literature
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