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TranscriptomicsA Novel Neuron-specific Histone H4K20 Demethylase LSD1n Promotes Transcriptional Elongation and is Essential for Learning and Memory
LSD1n regulates transcriptional elongation by removing H4K20 methylation. Identification of genome-wide binding sites of LSD1, and examination of the histone modifications upon LSD1n deletion in primary cortical neurons
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-63271 | biostudies-arrayexpress
ProteomicsProteomic analysis reveal pharmacological mechanism of Xueshuantong injection on preventing early acute myocardial infarction injury
This study was designed to investigate the efficacy and mechanism of XST in alleviating hyperacute myocardial infarction injury in rats. In addition, differential proteomics was used to explore the target protein of XST, and combined with bioinformatics analysis, the possible biological basis of its...
ORGANISM(S): Rattus Norvegicus 
2022-07-15 | PXD035370 |
ProteomicsEfficacy and Mechanism of Buyang Huanwu Decoction in Patients with Ischemic Heart Failure: A Randomized, Double-blind, Placebo-controlled Trial Combined with Proteomic Analysis
To assess the efficacy and safety of BYHWD combined with guideline-guided pharmacotherapy in patients with IHF and explore the biological mechanism by which BYHWD exerts its efficacy.
ORGANISM(S): Homo Sapiens 
2021-11-17 | PXD029771 |
GenomicsGlobal Mapping of H3K4me1 and H3K4me3 in human CD4+CD25+FOXP3+ Treg cells
Regulatory T cells (Treg) contribute to the crucial immunological processes of self-tolerance and immune homeostasis. However, the mechanisms underlying Treg function and cell fate decisions to differentiate between Treg and conventional T cells (Tconv) remain to be fully elucidated, especially at t...
ORGANISM(S): Homo sapiens 
2011-01-31 | E-GEOD-26427 | biostudies-arrayexpress
Proteomics4D label-free quantitative proteomics analysis of collagen-induced arthritis rats
4D label-free quantitative proteomics was performed to analysis the changes of protein expression in synovial tissues between Normal control group, Model control group and JTQBG treated group.
ORGANISM(S): Rattus Norvegicus 
2024-02-23 | PXD050056 |
ProteomicsQuantitative proteomics revealed the mechanism of Yiqi Huoxue recipe used to treat cerebral infarction with Qi deficiency and blood stasis
Huoxue Yiqi (HXYQ) recipe is widely used to treat cerebral infarction with Qi deficiency and blood stasis syndrome (CI-QDBS), but its pharmacological mechanism is still not clear. In this study, the serum samples of patients with Qi deficiency and blood stasis syndrome in the convalescent stage of c...
ORGANISM(S): Homo Sapiens 
2022-12-12 | PXD029388 |
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