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UnknownTypical Heterotrophic and Autotrophic Nitrogen Removal Process Coupled with Membrane Bioreactor: Comparison of Fouling Behavior and Characterization.
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S-EPMC11509564 | biostudies-literature
ProteomicsSystematic Metaproteomic Mapping of Ex vivo Gut Microbiota Functional Responses to Therapeutic Drugs (3)
Some therapeutic compounds can influence our gut microbiota, but a comprehensive understanding of their impact on microbial systems ecology remains largely unexplored. This study examines the impact of 312 therapeutic compounds on metaproteomes of six ex vivo human gut microbiota, generating 4.6 mil...
ORGANISM(S): human gut metagenome 
2025-08-28 | PXD056968 | Pride
Gut microbiota Microbiome Drug response Functional redundancy Metaproteomics 
ProteomicsSystematic Metaproteomic Mapping of Ex vivo Gut Microbiota Functional Responses to Therapeutic Drugs (2)
Some therapeutic compounds can influence our gut microbiota, but a comprehensive understanding of their impact on microbial systems ecology remains largely unexplored. This study examines the impact of 312 therapeutic compounds on metaproteomes of six ex vivo human gut microbiota, generating 4.6 mil...
ORGANISM(S): human gut metagenome 
2025-08-28 | PXD056930 | Pride
Systems ecology Gut microbiome Metaproteomics Functional response 
ProteomicsSystematic Metaproteomic Mapping of Ex vivo Gut Microbiota Functional Responses to Therapeutic Drugs (1)
Some therapeutic compounds can influence our gut microbiota, but a comprehensive understanding of their impact on microbial systems ecology remains largely unexplored. This study examines the impact of 312 therapeutic compounds on metaproteomes of six ex vivo human gut microbiota, generating 4.6 mil...
ORGANISM(S): human gut metagenome 
2025-08-28 | PXD056888 | Pride
Gut microbiota Drug response Metaproteomic Lc-ms/ms 
ProteomicsAn in vitro model maintaining taxon-specific functional activities of the gut microbiome
We developed and validated a 96-deep well plate-based culturing model named Mipro to maintain individuals’ microbiomes. The Mipro model quintupled viable bacteria count while maintained the functional and compositional profiles of individuals’ gut microbiomes.
ORGANISM(S): Escherichia coli 
2019-08-16 | PXD013600 | Pride
Gut microbiome In vitro culturing Metaproteomics 
ProteomicsFunctional effects of sweeteners on ex vivo human gut microbiome
We systematically investigated the responses of five human gut microbiomes to 21 common sweeteners, using an approach combining high-throughput ex vivo microbiome culturing and metaproteomics to quantify functional changes in different taxa. Hierarchical clustering based on metaproteomic responses ...
ORGANISM(S): human gut metagenome 
2022-06-23 | PXD030458 | Pride
Artificial sweetener  microbiome  metaproteomics 
ProteomicsProteome-Level Functional Redundancy in the Human Gut Microbiome
Here, we quantify the proteome-level functional redundancy in the human gut microbiome using metaproteomics and network approaches.In particular, we used an ultra-deep metaproteomics approach based on high-pH reverse phase fractionation. The data analysis revealed high protein-level functional redun...
ORGANISM(S): human gut metagenome 
2023-06-08 | PXD027297 | Pride
Gut microbiome Network Functional redundancy Metaproteomics 
ProteomicsThe role and underlying mechanism of exosomal CA1 in chemotherapy resistance in diffuse large B cell lymphoma
Tandem mass tag labeling proteomics was used to perform proteomic profiling in exosomes from chemo-sensitive and chemo-resistant DLBCL patients’ serum. A total of 391 proteins were detected by proteomics analysis, of which 54 differentially expressed protein (16 up-regulated proteins, 38 down-regula...
ORGANISM(S): Homo Sapiens 
2020-06-18 | PXD019780 |
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