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GenomicsGenome-wide mapping of HATs and HDACs in human CD4+ T cells
Histone acetyltransferases (HATs) and deacetylases (HDACs) function antagonistically to control histone acetylation. As acetylation is a histone mark for active transcription, HATs have been associated with active and HDACs with inactive genes. We describe here genome-wide mapping of HATs and HDACs ...
ORGANISM(S): Homo sapiens 
2009-08-20 | E-GEOD-15735 | biostudies-arrayexpress
UnknownMan/Cel5B, a Bifunctional Enzyme Having the Highest Mannanase Activity in the Hyperthermic Environment.
Not available
S-EPMC8007966 | biostudies-literature
TranscriptomicsRNA-DNA DIFFERENCES IN NASCENT RNA
RNA sequences are expected to be identical to their corresponding DNA sequences. Advances in technologies have enabled deep sequencing of nucleic acids that uncovered exceptions to the one-to-one relationship between DNA and RNA sequences. Previously in human cells, post-transcriptional RNA editin...
ORGANISM(S): Homo sapiens 
2014-02-21 | E-GEOD-39878 | biostudies-arrayexpress
GenomicsGenome-wide Analysis of Chromatin Interactions in Human Cells
Millions of cis-regulatory sequences have recently been found in the human genome, but the function of most cis-elements are not yet clear, in part due to the difficulty in determining their regulatory targets, which are often located millions of base pairs away and separated by one or more unrelate...
ORGANISM(S): Homo sapiens 
2013-10-20 | E-GEOD-43070 | biostudies-arrayexpress
GenomicsEpigenome analysis of DNA modification 5-hydroxymethylcytosine in normal, abnormal, and globozoospermia sperm genomes
Genome wide of 5-hydroxymethylcytosine profiling of normal and abnormal, and globozoospermia sperm genomes.Two semen samples were collected from a healthy man and a globozoospermia patient who had consulted a physician at ShengJing Hospital of China Medical University. Other semen samples obtained f...
ORGANISM(S): Homo sapiens 
2013-04-18 | E-GEOD-46135 | biostudies-arrayexpress
TranscriptomicsCharacterization of human plasma-derived exosomal RNAs
Exosomes, endosome-derived membrane microvesicles, contain a specific set of RNA transcripts that are involved in cell-cell communication and hold a great potential as disease biomarkers. To systemically characterize exosomal RNA profiles, we performed RNA sequencing analysis using three human plasm...
ORGANISM(S): Homo sapiens 
2013-05-15 | E-GEOD-45722 | biostudies-arrayexpress
TranscriptomicsInteraction with Human Bronchial Epithelial Cells in vitro Affects Gene Expression in Moraxella catarrhalis
In this study, DNA microarray technology was used to measure global gene expression in M. catarrhalis cells that had attached to human bronchial epithelial cells in culture. M. catarrhalis ATCC 43617 was allowed to attach (MOI~30) to a monolayer of 16HBE14 human bronchial epithelial cells for 2 hr i...
ORGANISM(S): Moraxella catarrhalis 
2014-03-24 | E-GEOD-12990 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of isolated human foetal L/M-opsin cone photoreceptor populations labelled using the AAV2/9.pR2.1.GFP reporter
Human cone photoreceptors represent a rare cell population of the human retina and are largely outnumbered by other retinal cell types. Despite their rarity, cone photoreceptors are critical for optimal daylight vision and their loss has the greatest impact on sight during the progression of retinal...
ORGANISM(S): Homo sapiens 
2018-04-20 | E-MTAB-6058 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed miRNAs in TGF-M-NM-21-knock down human colorectal cancer cell lines vs controls
To investigate the role of TGF-M-NM-21-regulated miRNAs in the progression of colorectal cancer,we performed comprehensive miRMA microarray analysis on RNA derived from typical human colorectal cancer cell lines and TGF-M-NM-21 knock-down human colorectal cancer cell lines. We identified a novel se...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-53338 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed miRNAs in TGF-M-NM-21-knock down rhabdmyosarcoma cell lines vs controls
To investigate the role of TGF-M-NM-21-regulated miRNAs in the progression of RMS,we performed comprehensive miRMA microarray analysis on RNA derived from typical RMS cell lines and TGF-M-NM-21 knock-down cell lines. We identified a novel set of TGF-M-NM-21-related miRNAs. Total RNA was isolated fro...
ORGANISM(S): Homo sapiens 
2012-09-13 | E-GEOD-40843 | biostudies-arrayexpress
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