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TranscriptomicsRNA-seq of mouse myeloma cell line SP 2/0 cells compared to naive B cells
Both multiple myeloma (MM) and systemic lupus erythematosus (SLE) are characterized with abnormal production of plasma cells. In both diseases, the process of B cells differentiate into plasmablast/plasma cell is disordered. Despite the continuous research on the development of prognostic factors an...
ORGANISM(S): Mus musculus 
2019-07-31 | E-MTAB-7112 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse myeloma cell line SP 2/0 overexpressed with BC094916 against vector control
We found that a novel gene BC094916 mRNA significantly decreased in plasma cells. Because of plasmablast-like, mus musculus myeloma SP 2/0 cell line was selected to test the effect of BC094916 overexpression on plasmablast/plasma cells. BC094916 cDNA (General Biosystems, Anhui, China) was cloned int...
ORGANISM(S): Mus musculus 
2019-08-07 | E-MTAB-7105 | biostudies-arrayexpress
TranscriptomicsMicroarray for LPS-stimulated B cells compared to unstimulated B cells
Both multiple myeloma (MM) and systemic lupus erythematosus (SLE) are characterized with abnormal production of plasma cells. To explore the novel therapeutic target to plasma cells, we determined the gene expression profile in plasma cells by affymetrix microarrays. LPS could effectively in vitro i...
ORGANISM(S): Mus musculus 
2019-08-01 | E-MTAB-7109 | biostudies-arrayexpress
TranscriptomicsMicroarray for B cells of TACI-IgG-treated MRL/lpr mice compared to control mice
Both multiple myeloma (MM) and systemic lupus erythematosus (SLE) are characterized with abnormal production of plasma cells. In both diseases, the process of B cells differentiate into plasmablast/plasma cell is disordered. Despite the continuous research on the development of prognostic factors an...
ORGANISM(S): Mus musculus 
2019-07-30 | E-MTAB-7106 | biostudies-arrayexpress
TranscriptomicsMicroarray for activated B cells compared to naive B cells
B cells encounter antigen to activate and then differentiate into plasma cells. Both multiple myeloma (MM) and some autoimmune diseases such as multiple sclerosis (MS) and systemic lupus erythematosus (SLE) are characterized with abnormal production of plasma cells. In both diseases, the process of ...
ORGANISM(S): Mus musculus 
2019-08-01 | E-MTAB-7110 | biostudies-arrayexpress
MetabolomicsDietary leucine restriction remodels the gut microbiota and serum glycerophospholipids to combat obesity

Abstract

Background The gut microbiota mediates dietary impacts on host metabolism, but the roles of specific amino acids remain elusive. We investigated the mechanism by which dietary leucine restriction combats obesity.

Methods Combining Mendelian randomization in humans with interv...

2025-11-07 | MTBLS13281 | MetaboLights
ProteomicsIdentification of phenanthrene transfer proteins in xylem sap
The differentially expressed proteins in wheat xylem sap after phenanthrene exposure were screened by the threshold (fold change≥1.5 for up-regulation or ≤ 0.67 for down-regulation, P<0.05). Peroxidase (A0A3B5XXD0) was significantly decreased after phenanthrene exposure (fold change≤0.67, P<0.05). B...
ORGANISM(S): Triticum Aestivum 
2021-09-15 | PXD028208 |
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