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MetabolomicsCancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-canc...
2018-07-10 | MTBLS626 | MetaboLights
TranscriptomicsInvestigation of gene expression signature induced by Alk5TD (active type I TGF-beta receptor)
BT474 cells stably expressing Alk5TD or vector (BT474-Alk5TD and BT474-pBMN, respectively) were compared for gene expression. Genes that were differentially expressed between the two cell lines were collected as the signature induced by Alk5TD expression. Keywords: Comparison of two cell types (BT47...
ORGANISM(S): Homo sapiens 
2008-04-29 | E-GEOD-11293 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human wild type and gefitinib-resistant A431 cancer cells
A431 wild-type (wt) cancer cell line is sensitive to treatment with EGFR tyrosine kinase inhibitors (TKIs). By culturing it chronically under gefitinib, it eventually becomes resistant (A431_GR cell). We know of a few proteins involved in this mechanism of drug resistance, but a cDNA exprssion array...
ORGANISM(S): Homo sapiens 
2008-04-06 | E-GEOD-10696 | biostudies-arrayexpress
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