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TranscriptomicsDifferentially expressed miRNAs in colon cancer tissues vs normal colon tissues
To investigate the role of miRNAs in the progression of colon cancer, we performed comprehensive miRMA microarray analysis on RNA derived from colon cancer tissues and normal colon tissues. We identified a novel set of colon cancer-related miRNAs. Total RNA was isolated from colon cancer tissues and...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-53339 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed miRNAs in TGF-M-NM-21-knock down rhabdmyosarcoma cell lines vs controls
To investigate the role of TGF-M-NM-21-regulated miRNAs in the progression of RMS,we performed comprehensive miRMA microarray analysis on RNA derived from typical RMS cell lines and TGF-M-NM-21 knock-down cell lines. We identified a novel set of TGF-M-NM-21-related miRNAs. Total RNA was isolated fro...
ORGANISM(S): Homo sapiens 
2012-09-13 | E-GEOD-40843 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed miRNAs in TGF-M-NM-21-knock down human colorectal cancer cell lines vs controls
To investigate the role of TGF-M-NM-21-regulated miRNAs in the progression of colorectal cancer,we performed comprehensive miRMA microarray analysis on RNA derived from typical human colorectal cancer cell lines and TGF-M-NM-21 knock-down human colorectal cancer cell lines. We identified a novel se...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-53338 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed miRNAs in TGF-M-NM-21-knock down mice CT26 colorectal cancer cell lines vs controls
To investigate the role of TGF-M-NM-21-regulated miRNAs in the progression of colorectal cancer,we performed comprehensive miRMA microarray analysis on RNA derived from CT26 cell lines and TGF-M-NM-21 knock-down CT26 cell lines. We identified a novel set of TGF-M-NM-21-related miRNAs. Total RNA was...
ORGANISM(S): Mus musculus 
2013-12-16 | E-GEOD-53337 | biostudies-arrayexpress
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
ProteomicsDiscovery of Itaconate-Mediated Lysine Acylation
Itaconate is an important anti-microbial and immunoregulatory metabolite involved in host-pathogen interactions. A key mechanistic action of itaconate is through the covalent modification of cysteine residues via Michael addition, resulting in “itaconation”. However, it is unclear whether itaconate ...
ORGANISM(S): Mus Musculus 
2023-02-28 | PXD040508 |
ProteomicsChemical Proteomic Profiling of Lysine Crotonylation by Bioorthogonal Probes in Mammalian Cells
we report an alkynyl-functionalized bioorthogonal chemical probe, Cr-alkyne, for the detection and identification of protein lysine crotonylation in mammalian cells.
ORGANISM(S): Homo Sapiens 
2024-07-04 | PXD053632 |
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