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ProteomicsNeutrophil-derived PAD4 induces citrullination of CKMT1 in epithelial cells to exacerbate mucosal inflammation
Objective Increased neutrophil extracellular trap-osis (NETosis) is a hallmark of inflammatory bowel disease (IBD). However, the mechanisms of NETosis formation and its detrimental effect on the intestinal epithelium remain poorly understood. Design Dextran sulfate sodium (DSS) induce colitis in pep...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD041504 | Pride
Peptidyl-arginine deiminase-4  citrullination  mitochondrial creatine kinase 1  neutrophil extracellular traps  intestinal epithelial cells  inflammatory bowel disease 
UnknownPirfenidone inhibits TGF-β1-induced metabolic reprogramming during epithelial-mesenchymal transition in non-small cell lung cancer.
Not available
S-EPMC10844763 | biostudies-literature
ProteomicsIL-33 stabilizes the transcription factor IRF1
Interleukin-33 (IL-33) functions both as a secreted cytokine and as a nuclear factor, with pleiotropic roles in tumor growth and immunity. Here, we explored its role in hepatocellular carcinoma (HCC) and identified that its nuclear function mediated a mechanism of immune escape.
ORGANISM(S): Homo Sapiens 
2022-12-28 | PXD039110 |
ProteomicsGated phosphorylated proteomics of LAIR1-overexpressed and LAIR1-control in GL261 cells
The total protein in GL261 cells was extracted, part of it was taken out for protein concentration determination and SDS-PAGE detection, and the other part was taken for trypsin digestion, peptide desalting, phosphorylation modification peptide enrichment and purification, and finally 4D-Labelfree d...
ORGANISM(S): Mus Musculus 
PXD042932 |
ProteomicsArrestin engagement of the metabotropic glutamate receptor mGlu5
Phosphorylation sites identified at the C-terminus of mGlu5 by mass spectrometry analysis
ORGANISM(S): Homo Sapiens 
PXD076479 |
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