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TranscriptomicsThe expression of small RNAs after prg-1 mutation
Piwi-related Argonaute proteins play important roles in maintaining germline integrity and fertility and have been linked to a class of germline-enriched small RNAs termed piRNAs. Caenorhabditis elegans encodes two Piwi family proteins called PRG-1 and PRG-2, and PRG-1 interacts with the C. elegans ...
ORGANISM(S): Caenorhabditis elegans 
2014-06-09 | E-GEOD-56272 | biostudies-arrayexpress
TranscriptomicsThe expression mRNAs after prg-1 mutation
Piwi-related Argonaute proteins play important roles in maintaining germline integrity and fertility and have been linked to a class of germline-enriched small RNAs termed piRNAs. Caenorhabditis elegans encodes two Piwi family proteins called PRG-1 and PRG-2, and PRG-1 interacts with the C. elegans ...
ORGANISM(S): Caenorhabditis elegans 
2014-06-09 | E-GEOD-56271 | biostudies-arrayexpress
TranscriptomicsMIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes
The piRNA machinery is known for its role in mediating epigenetic silencing of transposons. Recent studies suggest that this function also involves piRNA-guided cleavage of transposon-derived transcripts. As many piRNAs also appear to have the capacity to target diverse mRNAs, this raises the intrig...
ORGANISM(S): Mus musculus 
2015-04-09 | E-GEOD-67683 | biostudies-arrayexpress
ProteomicsNetwork pharmacology and multi-omics validation of the Jianpi-Yishen formula in the treatment of chronic kidney disease
This study utilized network pharmacology, RNA sequencing (RNA-seq), and metabolic analyses using in vivo and in vitro models to investigate the impact of the JPYS formula on inflammation and the immune system. Specifically, the study focused on macrophage polarization and metabolic changes that may ...
ORGANISM(S): Mus Sp. 
2025-01-10 | PXD059614 |
ProteomicsGlobal Profiling of RNA-Binding Protein Target Sites by LACE-seq
Proteomic analysis of Ago2-/- oocytes revealed that Ago2 interacted with endogenous small interfering RNAs (endo-siRNAs) to repress mRNA translation globally.
ORGANISM(S): Mus Musculus 
2021-05-07 | PXD025846 |
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