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MetabolomicsMetabolite signatures of diverse Camellia sinensis tea populations
Tea plants (Camellia sinensis) present an excellent system to study evolution and diversification of specialized metabolites due to their abundance in classes, numbers and contents. A large number of tea cultivars have been cultivated throughout the world not only because of their adaption to differ...
2020-10-05 | MTBLS1405 | MetaboLights
MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Human UPLC-MS/MS assays)

Progressive decline in lung function is a hallmark of chronic obstructive pulmonary disease (COPD). Although airway dysbiosis occurs in COPD, whether it contributes to disease progression remains unknown. Here, through a longitudinal analysis on 181 COPD individuals from two large cohorts involvi...

2023-06-12 | MTBLS5423 | MetaboLights
MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Murine UPLC-MS/MS assays)

Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease (COPD). Airway dysbiosis occurs in COPD, but whether it contributes to disease progression remains unknown. Here we showed, through a longitudinal analysis on two cohorts involving four UK centers, that basel...

2023-06-12 | MTBLS6894 | MetaboLights
ProteomicsCircBIRC6-2 inhibits transmissible gastroenteritis virus induced mitochondrial permeability transition pore opening by its encoding protein
Transmissible gastroenteritis virus (TGEV), a member of coronavirus, is the pathogen of TGE. We previously found 123 circular RNAs (circRNAs) were differential expression during activation of mitochondrial permeability transition in porcine intestinal epithelial cells-jejunum 2 cell line (IPEC-J2) ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-10-13 | PXD029055 | Pride
Lc-ms/ms Peptide analysis Interacting protein 
UnknownGenotype-Guided Dosing of Warfarin in Chinese Adults: A Multicenter Randomized Clinical Trial.
Not available
S-EPMC7439928 | biostudies-literature
ProteomicsDiscovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation
PKMYT1 has recently emerged as a compelling therapeutic target for precision cancer therapy due to its synthetic lethality with oncogenic alterations such as CCNE1 amplification and mutations in FBXW7 and PPP2R1A. Current small molecule PKMYT1 inhibitors face limitations, such as insufficient molecu...
ORGANISM(S): Homo sapiens (Human) 
2025-09-28 | PXD062889 | Pride
Protac Pkmyt1 Synthetic lethality Ai-generation 
UnknownTNFRSF13B Variant-Induced TACI Dysregulation Underlies CAEBV Pathogenesis.
Not available
S-EPMC12830494 | biostudies-literature
MetabolomicsPregnancy-Induced Metabolic Phenotype Variations in Maternal Plasma
Metabolic variations occur during normal pregnancy to provide the growing fetus with a supply of nutrients required for its development and to ensure the health of the woman during gestation. Mass spectrometry-based metabolomics was employed to study the metabolic phenotype variations in the materna...
2015-03-03 | MTBLS146 | MetaboLights
ProteomicsProteomics analysis of three tea cultivars
To decipher phenotypic differences in flavonoid metabolism and the abundance of UGT enzymes involved in flavonol glycoside biosynthesis, an integrated proteomics and metabolomics analysis was conducted on three tea cultivars (Camellia sinensis), namely Jinfenghuang, Fuyun 6 and Bantianyao.
ORGANISM(S): Camellia Sinensis 
2024-01-30 | PXD048997 |
MetabolomicsExploring the gut microbiome and serum metabolome interplay in non-functioning pituitary neuroendocrine tumors.

The gut microbiome has emerged as a potential factor in cancer pathogenesis, but its role in non-functioning pituitary neuroendocrine tumors (NF-PitNETs) remains unclear. This study aimed to elucidate gut microbiome and metabolomic alterations in NF-PitNETs by comparing microbial diversity, patho...

2025-06-16 | MTBLS12328 | MetaboLights
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