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ProteomicsNon-metabolic PHGDH facilitates cMyc to urge advanced liver cancer
Metabolic dysregulation is an important feature of malignant tumors. Serine synthesis pathway (SSP) reshapes tumor cells to enhance their growth and survival capabilities, especially under serine starvation. However, whether and how SSP is involved in the progression of liver cancer has not been cle...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD017809 | Pride
Serine synthesis Hepatocellular carcinoma Phgdh Proteome 
UnknownA CRISPR-Cas9 screen reveals genetic determinants of the cellular response to decitabine.
Not available
S-EPMC11933316 | biostudies-literature
ProteomicsMultiplexed Proteome Profiling of Targeted Protein Degradation With Data-Independent Acquisition-Based Mass Spectrometry
Targeted protein degradation (TPD) has become a powerful and promising tool that can effective trigger the degradation of specific disease-related proteins utilizing the endogenous pathways of the organism. However, the global proteomic profiling of TPD with multiple dimensions remains lacking since...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-03-06 | PXD050426 |
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