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Temperature is one of the primary environmental factors that affect aging, in which protein phosphorylation is an important regulator. Currently, the understanding of phosphorylation events in regulatory networks during aging has remained rather limited. Therefore, the phosphoproteomes of C.elegans ...
ORGANISM(S): Caenorhabditis elegans 
2018-08-08 | PXD009661 | Pride
Environmental factors such as temperature can modulate animal’s lifespan. However, the underlying mechanisms remain largely undefined. Through proteomic analysis of C. elegans at different time points (young adult, middle age, and old age) and under two temperature conditions (20°C and 25°C), we fou...
ORGANISM(S): Caenorhabditis elegans 
2023-03-11 | PXD024916 | Pride
Our multi-omics analysis of local patients demonstrated significant distinctions compared to TCGA-THCA cohorts, highlighting the unique genetic characteristics of Chinese individuals with PTC. We identified novel biomarkers that hold potential for diagnosis and prognosis of PTC. Furthermore, develop...
ORGANISM(S): Homo Sapiens 
2023-08-23 | PXD044815 |
The filter-aided sample preparation (FASP) method has been commonly used for proteomic sample preparation due to its high efficiency and convenience. Herein, we report an overlooked side reaction during FASP method, resulting in a mass increment of 12 Da. We confirmed that the side reaction is cause...
ORGANISM(S): Caenorhabditis elegans 
2020-08-20 | PXD018737 | Pride
Shotgun (bottom-up) approach has been widely applied in large-scale proteomics studies. The inherent shortages of shotgun approach lie in that the generated peptides often overwhelm the analytical capacity of current LC-MS/MS systems and that abundant proteins often hamper the identification of prot...
ORGANISM(S): Homo sapiens (Human) 
2017-11-30 | PXD007863 | Pride
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