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MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
ProteomicsProteomic analysis of chronic skin wounds in diabetic mice following electrical stimulation therapy delivered by a novel electrostimulation-hydrogel wound dressing
In this study, we established a type 2 diabetes model in C57BL/6 mice through high-fat diet induction and STZ injection. Based on this animal model, we simulated clinically common hard-to-heal chronic diabetic skin wounds by implanting a mixed bacterial fluid, including Methicillin-resistant Staphyl...
ORGANISM(S): Mus Musculus 
2023-08-29 | PXD044920 |
ProteomicsProteome of Chinese Breast Cancers (FUSCC-Shao Lab)
Raw data of TMT-labeled proteome of Chinese breast cancers. Uploaded by Zhi-Ming Shao Lab, Fudan University Shanghai Cancer Center (FUSCC)
ORGANISM(S): Homo Sapiens 
PXD042886 |
GenomicsReduced representation bisulfite sequencing from G0 & G4/G5 CMP
Differential hyper- and hypo-methylation regions in G0 versus G4/G5 CMP The goal of this study is to evaluate changes in CpG methylation profilings of telomere dysfunctional common myeloid progenitor cells (CMP) as compared to their wild type controls Genomic DNA was extracted from sorted CMP popula...
ORGANISM(S): Mus musculus 
2015-04-09 | E-GEOD-62392 | biostudies-arrayexpress
UnknownTelomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome.
Not available
S-EPMC4596059 | biostudies-literature
UnknownUltrahigh-energy gamma-ray emission associated with black hole-jet systems.
Not available
S-EPMC12746838 | biostudies-literature
UnknownRelationship Between Preexisting Cardiovascular Disease and Death and Cardiovascular Outcomes in Critically Ill Patients With COVID-19.
Not available
S-EPMC9575399 | biostudies-literature
UnknownObservation of quantum entanglement with top quarks at the ATLAS detector.
Not available
S-EPMC11410654 | biostudies-literature
UnknownTransforming jet flavour tagging at ATLAS.
Not available
S-EPMC12804921 | biostudies-literature
UnknownGlobal age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535839 | biostudies-literature
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