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ProteomicsHistone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis
Histone chaperones and chromatin remodelers control nucleosome dynamics, essential for transcription, replication, and DNA repair. The histone chaperone Anti-Silencing Factor 1 (ASF1) plays a central role in facilitating CAF-1-mediated replication-dependent H3.1 deposition and HIRA-mediated replicat...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-10-31 | PXD035578 | Pride
Arabidopsis Lcms Proteomics 
ProteomicsThe MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.
MOM1 is an Arabidopsis factor previously shown to mediate transcriptional silencing independent of major DNA methylation changes. Here we found that MOM1 localizes with sites of RNA-directed DNA methylation (RdDM). Tethering MOM1 with artificial zinc finger to unmethylated FWA promoter led to establ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-06-10 | PXD039991 | Pride
Mom1 Arabidopsis Lcms 
ProteomicsMYCT1 CONTROLS ENVIRONMENTAL SENSING IN HUMAN HEMATOPOIETIC STEM CELLS
Hematopoietic stem cells (HSC) rely on a unique regulatory machinery that facilitates life-long blood production and enables reconstitution of the entire hematopoietic system upon transplantation. However, the biological processes governing human HSC self-renewal and engraftment ability are poorly u...
ORGANISM(S): Homo sapiens (Human) 
2024-04-15 | PXD042257 | Pride
Myct1 Proteomics Stem cells 
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