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ProteomicsUSP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for the treatment of solid tumors, the reasons for which remain ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD045622 | Pride
Usp36  snail1  ribosome biogenesis  ribotoxic stress 
UnknownTrial watch: immunotherapeutic strategies on the horizon for hepatocellular carcinoma.
Not available
S-EPMC10241000 | biostudies-literature
UnknownChronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response.
Not available
S-EPMC5879702 | biostudies-literature
UnknownLoss of a Negative Feedback Loop between IRF8 and AR Promotes Prostate Cancer Growth and Enzalutamide Resistance.
Not available
S-EPMC9601976 | biostudies-literature
UnknownApoE maintains neuronal integrity via microRNA and H3K27me3-mediated repression.
Not available
S-EPMC10909902 | biostudies-literature
UnknownPotentially functional SNPs (pfSNPs) as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients.
Not available
S-EPMC4221105 | biostudies-literature
UnknownMethylmalonic and propionic acidemia among hospitalized pediatric patients: a nationwide report.
Not available
S-EPMC6915987 | biostudies-literature
UnknownInfluence of glycan structure on the colonization of Streptococcus pneumoniae on human respiratory epithelial cells.
Not available
S-EPMC10068763 | biostudies-literature
TranscriptomicsSAGE Profiles of Rat Lung Tissues
Thirty-two SD rats (male, 150 grams, 50days) were randomly divided into four groups: normal control group, asthma group, acupuncture-treated asthma group and acupuncture-treated normal group. The rat lungs were removed immediately after the rats were died. The rat lungs were conserved in liquid nitr...
ORGANISM(S): Rattus norvegicus 
2005-04-09 | E-GEOD-2475 | biostudies-arrayexpress
UnknownRising global burden of cancer attributable to high BMI from 2010 to 2019.
Not available
S-EPMC11321712 | biostudies-literature
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