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ProteomicsThe crosstalk between CRL5 and APC/C E3 ligases regulates metastasis and chemo-sensitivity of cancer cells
Cullin-RING ligases (CRLs) and the anaphase-promoting complex/cyclosome (APC/C) are two major multi-subunit ubiquitin ligases essential for protein homeostasis. The underlying mechanism and biological consequence of their crosstalk remain elusive. Here, we employed tandem affinity purification follo...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD068961 | Pride
Cul5  apc11  neddylation  metastasis  chemo-sensitivity 
UnknownIdentification of miRNA biomarkers for essential hypertension in small samples based on MPGAM.
Not available
S-EPMC12559234 | biostudies-literature
UnknownBRD7 suppresses tumor chemosensitivity to CHK1 inhibitors by inhibiting USP1-mediated deubiquitination of CHK1.
Not available
S-EPMC10457387 | biostudies-literature
UnknownRHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis.
Not available
S-EPMC11832924 | biostudies-literature
UnknownDEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity.
Not available
S-EPMC7661726 | biostudies-literature
UnknownFunctional characterization of FBXL7 as a novel player in human cancers.
Not available
S-EPMC9338262 | biostudies-literature
UnknownDEPTOR suppresses lymphomagenesis by promoting EGFR degradation via HUWE1 E3 ligase.
Not available
S-EPMC12501038 | biostudies-literature
GenomicsWdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network
The embryonic stem (ES) cell transcriptional and epigenetic networks are critical for the maintenance of ES cell self-renewal. However, it remains unclear whether components of these networks functionally interact and if so, what factors mediate such interactions. Here we show that WD-repeat protein...
ORGANISM(S): Mus musculus 
2011-04-08 | E-GEOD-22934 | biostudies-arrayexpress
ProteomicsA Tissue-Specific Atlas of Mouse N-Glycoproteome
In this study, we employed StrucGP to generate the first high-resolution and site-specific N- glycoproteomic atlas across 24 diverse mouse tissues. This comprehensive dataset provides an unprecedented insight into the tissue-specific landscape of N-glycosylation, revealing how distinct glycan struct...
ORGANISM(S): Mus Musculus 
2025-05-07 | PXD063701 |
ProteomicsSite-specific N-glycoproteomics of aging mouse uterus tissues for benchmarking the StrucGAP analysis platform
This project presents the site-specific N-glycoproteomics dataset of aging mouse uterus tissues used to demonstrate and validate StrucGAP, a modular and scalable downstream analysis platform for glycoproteomics. Uterine samples were collected from 2- and 12-month-old C57BL/6 female mice (n = 15 per ...
ORGANISM(S): Mus Musculus 
2025-04-23 | PXD063260 |
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