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UnknownActive Compounds and Targets of Yuanzhi Powder in Treating Alzheimer's Disease and Its Relationship with Immune Infiltration Based on HPLC Fingerprint and Network Pharmacology.

Background

Yuanzhi powder (YZP) has been extensively investigated as a natural prescription with therapeutic benefits for Alzheimer's disease (AD). However, its active compounds and underlying immune mechanism for treating AD are still unclear. This study aimed to investigate the immune mech...
S-EPMC9307349 | biostudies-literature
UnknownPharmacometabolomics and mass spectrometry imaging approach to reveal the neurochemical mechanisms of Polygala tenuifolia.
Polygala tenuifolia, commonly known as Yuanzhi (YZ) in Chinese, has been shown to possess anti-insomnia properties. However, the material basis and the mechanism underlying its sedative-hypnotic effects remain unclear. Herein, we investigated the active components and neurochemical mechanism ...
S-EPMC11340588 | biostudies-literature
UnknownFirst Molecular Evidence of <i>Babesia caballi</i> and <i>Theileria equi</i> in Imported Donkeys from Kyrgyzstan.
Equine piroplasmosis (EP) is an important tick-borne disease of equids, caused by Theileria equi, Theileria haneyi, and Babesia caballi. Nonetheless, there has been a scarcity of systematic reports on EP parasites in donkeys in Kyrgyzstan, Central Asia. In this study, piroplasms were screened in 190...
S-EPMC11434632 | biostudies-literature
UnknownCNPase, a 2',3'-Cyclic-nucleotide 3'-phosphodiesterase, as a Therapeutic Target to Attenuate Cardiac Hypertrophy by Enhancing Mitochondrial Energy Production.
Heart failure is the end-stage of all cardiovascular diseases with a ~25% 5-year survival rate, and insufficient mitochondrial energy production to meet myocardial demand is the hallmark of heart failure. Mitochondrial components involved in the regulation of ATP production remain to be fully elucid...
S-EPMC8509266 | biostudies-literature
UnknownNormal Workflow and Key Strategies for Data Cleaning Toward Real-World Data: Viewpoint.
With the rapid development of science, technology, and engineering, large amounts of data have been generated in many fields in the past 20 years. In the process of medical research, data are constantly generated, and large amounts of real-world data form a "data disaster." Effective data analysis a...
S-EPMC10557005 | biostudies-literature
UnknownMoSe2-Ni3Se4 Hybrid Nanoelectrocatalysts and Their Enhanced Electrocatalytic Activity for Hydrogen Evolution Reaction.
Combining MoSe2 with other transition metal dichalcogenides to form a hybrid nanostructure is an effective route to enhance the electrocatalytic activities for hydrogen evolution reaction (HER). In this study, MoSe2-Ni3Se4 hybrid nanoelectrocatalysts with ...
S-EPMC7297896 | biostudies-literature
ProteomicsIntegrated Protein Precipitation–SPE Workflow for Deep Top-Down Proteomic Analysis of Human Serum
Top-down proteomics of human serum is hindered by extreme dynamic range and cumbersome prefractionation. Here we establish a fully solution-based protein precipitation–solid-phase extraction (PP–SPE) workflow for deep, low-molecular-weight-biased proteoform profiling. Using systematically optimized ...
ORGANISM(S): Homo Sapiens 
PXD073228 |
ProteomicsOLFM4 is a direct target of the cGAS-STING pathway and acts as an extracellular inhibitor for the Hippo signaling in EBV-associated cancer
To investigate protein components of MVs in EBVaGC, we collected clinical tissue samples of 3 EBV+ and 3 EBV- gastric cancer patients, and isolated MVs from these samples. Then performed 4D-label free quantitative proteomics analysis for each isolated MVs. Raw files of 6 samples are included in subp...
ORGANISM(S): Homo Sapiens 
2024-11-18 | PXD057977 |
ProteomicsThe targets study of HDCA in ameliorating NAFLD induced by high-calories diet by multi-omics technology
HDCA supplementation ameliorated diet-induced NAFLD in C57 wild type mice. In attempt to comprehensively understand the molecular mechanism occurring during the protective effect of HDCA, transcriptomic and proteomic profiles of mouse liver were first analyzed utilizing RNA-Sequencing and Tandem Mas...
ORGANISM(S): Mus Musculus 
PXD044613 |
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