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ProteomicsModulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy
Although many affinity adsorbents have been developed for phosphopeptides enrichment, high-specifically capturing the multi-phosphopeptides is still a big challenge. Here, we investigated the mechanism of phosphate ions coordination and substitution on affinity adsorbents surfaces and modulated the ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080735 | MassIVE
ProteomicsShuangxinfang in Rats with Depression-behavior post Acute Myocardial Infarction from Proteomics
AMI models were established and PCF was administered in rats. Subjects were then assessed in an open field test recapitulating symptoms of depression. Afterward, pharmacoproteomic profiling of the hippocampus and peri-infarct border zone (BZ) was performed using a label-free liquid chromatography-ta...
ORGANISM(S): Rattus Norvegicus 
PXD027832 |
ProteomicsGlobal quantification of intact proteins via chemical isotope labeling and mass spectrometry
Although thousands of intact proteins can be feasibly identified in recent years, global quantification of intact proteins is still challenging. Herein, we develop a high-throughput strategy for global intact protein quantification based on chemical isotope labeling. The isotope incorporation effici...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-04-30 | PXD012526 | Pride
Intact protein quantification Ptop Chemical isotope labeling Highest isotopic peak Mass spectrometry 
ProteomicsModulating the selectivity of affinity absorbents to multi-phosphopeptides by a novel competitive substitution strategy
Although many affinity adsorbents have been developed for phosphopeptides enrichment, high-specifically capturing the multi-phosphopeptides is still a big challenge. Here, we investigated the mechanism of phosphate ions coordination and substitution on affinity adsorbents surfaces and modulated the ...
ORGANISM(S): Homo sapiens (Human) 
2016-08-03 | PXD004252 | Pride
Mass spectrometry Multi-phosphopeptide enrichment Pre-coordination Phosphoproteomics Competitive substitution 
MetabolomicsA metabolome atlas of mouse brain on the global metabolic signature dynamics following short-term fasting
Calorie restriction (CR) or a fasting regimen is considered one of the most potent non-pharmacological interventions to prevent chronic metabolic disorders, ameliorate autoimmune diseases, and attenuate aging. Despite efforts, the mechanisms by which CR improves health, particularly brain health, ar...
2025-07-31 | MTBLS8006 | MetaboLights
ProteomicsIntegrated Protein Precipitation–SPE Workflow for Deep Top-Down Proteomic Analysis of Human Serum
Top-down proteomics of human serum is hindered by extreme dynamic range and cumbersome prefractionation. Here we establish a fully solution-based protein precipitation–solid-phase extraction (PP–SPE) workflow for deep, low-molecular-weight-biased proteoform profiling. Using systematically optimized ...
ORGANISM(S): Homo Sapiens 
PXD073228 |
ProteomicsProteomic landscape of serum exosomes to identify potential therapeutic targets.
Using a tandem mass tag (TMT)-based quantitative proteomics approach, we characterized the proteomes of individual patient-derived serum exosomes, identified exosomal protein signatures specific to TNBC patients, and filtered out differentially expressed proteins.
ORGANISM(S): Homo Sapiens 
2021-08-04 | PXD027696 |
Proteomics[HPP-2.0] Motif-dependent immune co-receptor interactome profiling by photoaffinity chemical proteomics
Phosphotyrosine Motif-dependent synthetic CD28 interactome
ORGANISM(S): Homo Sapiens 
2024-02-06 | PXD049270 |
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