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TranscriptomicsGene expression analysis of TIL rich HPV driven head and neck tumours reveals a distinct B-cell signature when compared to HPV independent tumours.
Purpose: Human papilloma virus (HPV) associated head and neck squamous cell carcinoma (HNSCC) has a better prognosis than HPV(-) negative cancer. This may be due, in part, to the higher number of tumour infiltrating lymphocytes (TIL) in HPV(+) tumours. We used RNAseq to evaluate whether these differ...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-72536 | biostudies-arrayexpress
UnknownFalls prevention in an older adult mental health ward through a quality improvement initiative.
Not available
S-EPMC11683928 | biostudies-literature
UnknownAltered tyrosine metabolism and B lymphocyte profiles are associated with disease severity in pediatric anti-NMDAR encephalitis: a cross-sectional study.
Not available
S-EPMC12579682 | biostudies-literature
UnknownCellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments.
Not available
S-EPMC3119736 | biostudies-literature
UnknownRe-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs.
Not available
S-EPMC7152998 | biostudies-literature
UnknownBiogeography of American Northwest Hot Spring A/B'-Lineage Synechococcus Populations.
Not available
S-EPMC7050468 | biostudies-literature
UnknownEnhanced preoperative education about continuous femoral nerve block with patient-controlled analgesia improves the analgesic effect for patients undergoing total knee arthroplasty and reduces the workload for ward nurses.
Not available
S-EPMC6693176 | biostudies-literature
UnknownHuman Norovirus Triggers Primary B Cell Immune Activation In Vitro.
Not available
S-EPMC9040803 | biostudies-literature
UnknownMediation Analysis of the Relationship Between Health Literacy and the French General Population's Opinions on Hepatitis B Vaccination: Representative Cross-Sectional Survey of the SLAVACO Project.
Not available
S-EPMC12949401 | biostudies-literature
ProteomicsRe-evaluation of the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: CIAPIN1 is a major target of VLX1570 for non-selective covalent modification and aggregation in a multiple myeloma model.
Deubiquitinating enzymes are a growing target class across multiple disease states, with several inhibitors now reported. b-AP15 and VLX1570 are two structurally related USP14/UCH-37 inhibitors. Initially taken forward into a phase I/II clinical trial for refractory Multiple Myeloma, VLX1570 has sin...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD015412 | Pride
Proteomics Vlx1570 Chemoproteomics Bap-15 Multiple myeloma 
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