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Background: Septic Emergency Department (ED) patients provide a unique opportunity to investigate early sepsis. Recent work focuses on exosomes, nanoparticle-sized lipid vesicles (30-130nm) that are released into the bloodstream to transfer its contents (RNA, miRNA, DNA, protein) to other cells. Lit...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-06-29 | MSV000085646 | MassIVE
Patients were recruited between February 2008 and March 2019 through the Activation of Coagulation and Inflammation in Trauma (ACIT-II) study, a prospective platform cohort study evaluating aspects of coagulation and inflammation in trauma patients (NHS REC: 07/Q0603/20). Patients at the Royal Londo...
ORGANISM(S): Homo sapiens 
Mutation of the adenomatous polyposis coli (APC gene), an early event in the adenoma-carcinoma sequence, is present in 70-80% of sporadic human colorectal adenomas and carcinomas. To test the hypothesis that mutation of the APC gene alters microbial interactions with host intestinal mucosa prior to...
ORGANISM(S): Mus musculus 
The CUG-BP and ETR-3-like factor 1 (Celf1) RNA binding protein plays an important role in heart and muscle development, and is over-expressed in the disease myotonic dystrophy. Celf1 has known roles in regulation of RNA splicing, RNA stability, and protein translation. To identify transcriptome-wi...
ORGANISM(S): Mus musculus 
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