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TranscriptomicsA High-Fat Diet and NAD+ Rescue Premature Aging in Cockayne Syndrome
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in the genes encoding the DNA repair proteins CSA or CSB. Csbm/m mice were given a high-fat, caloric-restricted or resveratrol-supplemented diet. The high-fat diet rescued the p...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-62194 | biostudies-arrayexpress
TranscriptomicsMethylation Profiling of Blood DNA from Healthy Children (Harvard Age Study)
Analysis of the DNA methylation level in peripheral blood leukocytes from healthy children using the Illumina HumanMethylation450 BeadChip Groupings by family membership requested but not provided by submitter DNA methylation association study in healthy children
ORGANISM(S): Homo sapiens 
2012-02-24 | E-GEOD-36064 | biostudies-arrayexpress
UnknownMicrosatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803.
Not available
S-EPMC3157981 | biostudies-literature
ProteomicsIdentifying nucleic acid-associated proteins in Mycobacterium smegmatis by mass spectrometry-based proteomics
Background: The intracellular pathogen Mycobacterium tuberculosis is known to encounter several stress conditions during infection, including low pH, hypoxia, starvation and oxidative and nitrosative stress. Mycobacterial adaptation to stress conditions is, in part, mediated by several nucleic acid-...
ORGANISM(S): Mycobacterium smegmatis Bacteria 
2020-03-05 | PXD016241 | Pride
Nucleic acid-associated proteins Affinity-purification Mycobacterium Rna polymerase 
UnknownA megastudy of text-based nudges encouraging patients to get vaccinated at an upcoming doctor's appointment.
Not available
S-EPMC8157982 | biostudies-literature
UnknownActivation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease.
Not available
S-EPMC2994971 | biostudies-literature
UnknownPhase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma.
Not available
S-EPMC4021043 | biostudies-literature
TranscriptomicsWhite Matter transcriptome in chronic alcoholism
Chronic alcohol consumption can lead to alchohol-related brain damage (ARBD). Despite the well known acute effects of alcohol the mechanism responsible for chronic brain damage is largely unknown. Pathologically the major change is the loss of white matter while neuronal loss is mild and restricted ...
ORGANISM(S): Homo sapiens 
2014-01-04 | E-GEOD-53808 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human adipose tissue from hypopituitary men before and after growth hormon (GH) treatment.
Adipose tissue is a major target of GH action. GH stimulates lipolysis and reduces fat mass. The molecular mechanism underlying cellular and metabolic effects of GH in adipose tissue is not well understood. The aim of this study is to identify GH-responsive genes that regulate lipid metabolism in ad...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MTAB-276 | biostudies-arrayexpress
UnknownThe Phosphorylated Estrogen Receptor α (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2.
Not available
S-EPMC6336141 | biostudies-literature
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