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MetabolomicsWhole blood metabolomics of dementia patients reveal classes of disease-linked metabolites

Dementia is caused by factors that damage neurons. We quantified small molecular markers in whole blood of dementia patients, using non-targeted liquid chromatography-mass spectroscopy (LC-MS). Thirty-three metabolites, classified into 5 groups (A-E), differed significantly in dementia patients, ...

2021-07-06 | MTBLS2109 | MetaboLights
TranscriptomicsExpression data from mouse preimplantation cloned embryos
Transcriptiome analysis is an excellent approach to understand the mechanism underlying nuclear reprogramming in somatic-cell-cloned embryos. Analysis of the transcriptomic data from the oocyte to blastocyst stage revealed that specific genes were inappropriately reprogrammed at each stage. Sertoli ...
ORGANISM(S): Mus musculus 
2013-04-05 | E-GEOD-41358 | biostudies-arrayexpress
TranscriptomicsPARVB overexpression increases migration capability and defines high risks for endophytic growth and metastasis in tongue squamous cell carcinoma.
Tongue squamous cell carcinoma (TSCC) varies in characteristics even in early stages and is mainly classified into three subtypes, which are superficial, exophytic and endophytic types, based on a macroscopic appearance of tumor growth.Of these subtypes, endophytic tumor has a poorer prognosis becau...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-52915 | biostudies-arrayexpress
UnknownVersican is crucial for the initiation of cardiovascular lumen development in medaka (Oryzias latipes).
Not available
S-EPMC6603046 | biostudies-literature
ProteomicsA transphyletic study of metazoan β-catenin protein complexes
β-catenin plays a vital role in various biological processes, such as body axis determination and cell differentiation, during embryonic development in metazoans. These β-catenin functions are thought to be exerted through complexes formed with various types of proteins. Although β-catenin complex p...
ORGANISM(S): Cellular Organisms 
2025-01-21 | PXD053223 | JPOST Repository
TranscriptomicsGene expression in the whole brains of two spontaneously hypertensive rat strains at 3 and 6 weeks of age
We examined gene expression profiles in the rat whole brains using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains: normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP). To identify candidate genes involved in the genesis o...
ORGANISM(S): Rattus norvegicus 
2014-01-24 | E-GEOD-41452 | biostudies-arrayexpress
UnknownThe pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency.
Not available
S-EPMC8184003 | biostudies-literature
TranscriptomicsGene expression in the adrenal glands of two spontaneously hypertensive rat strains at 3 and 6 weeks of age
We examined gene expression profiles in the rat adrenal glands using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains: normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP). To identify candidate genes involved in the genesis...
ORGANISM(S): Rattus norvegicus 
2013-04-16 | E-GEOD-31457 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsFruit setting rewires central metabolism via gibberellin cascades
Fruit set is the process whereby ovaries develop into fruits after pollination and fertilization. The process is induced by the phytohormone gibberellin (GA) in tomatoes, as determined by the constitutive GA response mutant procera However, the role of GA on the metabolic behavior in fruit-setting o...
2020-09-11 | MTBLS1892 | MetaboLights
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